Dr. Peter Attia

And is the main selling point, because most patients just want things taken out, I have cancer, take it out, is the reason that a person might select radiation therapy, especially if it comes with androgen deprivation therapy, because of the sexual function and urinary function? What's the main advantage?

And is the main selling point, because most patients just want things taken out, I have cancer, take it out, is the reason that a person might select radiation therapy, especially if it comes with androgen deprivation therapy, because of the sexual function and urinary function? What's the main advantage?

And I know we've talked about this before. You're just not seeing the proctitis. Yes, almost none.

And I know we've talked about this before. You're just not seeing the proctitis. Yes, almost none.

And does the patient need to be coached to time their breath or anything as the beam is at that most delicate edge of the rectum?

And does the patient need to be coached to time their breath or anything as the beam is at that most delicate edge of the rectum?

Everybody I've talked to who's had LASIK eye surgery always says they're so worried that they're going to do something, they're going to flinch. And do patients feel the same way when they're undergoing radiation? Like, what if I just flinch my pelvis or do something like that? It's going to get too close.

Everybody I've talked to who's had LASIK eye surgery always says they're so worried that they're going to do something, they're going to flinch. And do patients feel the same way when they're undergoing radiation? Like, what if I just flinch my pelvis or do something like that? It's going to get too close.

What about patients that are inoperable? First of all, what leads to a patient being inoperable and how do they show up?

What about patients that are inoperable? First of all, what leads to a patient being inoperable and how do they show up?

Now, is this an apples to apples comparison? Because the patient who undergoes the robotic prostatectomy today does not go on androgen deprivation therapy. They get to walk around. In fact, you've probably heard Ted on the podcast. He says, we'll give those patients TRT if they're hypogonadal.

Now, is this an apples to apples comparison? Because the patient who undergoes the robotic prostatectomy today does not go on androgen deprivation therapy. They get to walk around. In fact, you've probably heard Ted on the podcast. He says, we'll give those patients TRT if they're hypogonadal.

Why does the patient after radiation therapy still need to be androgen deprived if in theory the radiation is as effective as the surgery?

Why does the patient after radiation therapy still need to be androgen deprived if in theory the radiation is as effective as the surgery?

Has there been a trial of Gleason 3 plus 3 watchful waiting versus XRT no ablation? No. Unfortunately, there's no actual trial. There's just observational studies. That's kind of what we're dealing with there. Oh, gosh. And obviously, you can't figure out what the biases are. But what do those observational studies show?

Has there been a trial of Gleason 3 plus 3 watchful waiting versus XRT no ablation? No. Unfortunately, there's no actual trial. There's just observational studies. That's kind of what we're dealing with there. Oh, gosh. And obviously, you can't figure out what the biases are. But what do those observational studies show?

So it's really interesting. There would be a very interesting and elegant study taking, let's call it medium to high risk 3 plus 3s. So people based on family history or some other phenomenon, genetic or otherwise, you randomize them to watchful waiting versus radiate them without androgen deprivation. I mean, you'd have to do this as a very long-term study.

So it's really interesting. There would be a very interesting and elegant study taking, let's call it medium to high risk 3 plus 3s. So people based on family history or some other phenomenon, genetic or otherwise, you randomize them to watchful waiting versus radiate them without androgen deprivation. I mean, you'd have to do this as a very long-term study.

So the question is, outcome number one could be conversion to three plus seven requiring surgery and or androgen deprivation therapy. And then of course, outcome two, the very long-term outcome would be overall survival. That's the key.

So the question is, outcome number one could be conversion to three plus seven requiring surgery and or androgen deprivation therapy. And then of course, outcome two, the very long-term outcome would be overall survival. That's the key.