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Aaron Boster

👤 Person
887 total appearances

Appearances Over Time

Podcast Appearances

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And what's exciting is that it was a very successful result.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Compared to placebo, the patients on the BTK inhibitor slowed progression by 29%, which is a really big deal.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

This medication has been fast-tracked at the American FDA, and we believe that probably come September timeframe, we may have the first FDA-approved therapy for non-relapsing secondary progressive MS.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

What's even more exciting is that the same molecule, the telobrutinib molecule, is being studied in primary progressive MS in a clinical trial called the Perseus trial.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Now, we should be getting a readout for Perseus sometime later this year, and our fingers are crossed.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

I'll cross my fingers for you.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

How crestfallen are you?

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

My honest answer is I don't think that we're going to see a cure in my lifetime.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Yeah.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And I'm not saying that to be a Debbie Downer.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

The reason I say that is our understanding of the immune system remains fledgling.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We, for example, are just now starting to be able to impact the innate immune response, which is bigger than the adaptive immune response.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

So most of our drugs that we've developed affect B and T cells.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

There's another part of our immune system, which is way bigger than that.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And we're just now studying drugs that can get at it.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

I think given our meager understanding of the immune system, which is really one of the last frontiers, I think it's unrealistic that we're going to cure MS in the near term.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Now, I want to be really clear that in medicine, we cure nearly nothing.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

So we don't cure high blood pressure.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We treat high blood pressure.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

So I have high cholesterol.