Dr. Anne Chappelle

My name is Anne Chappelle. I am a board-certified toxicologist with over 25 years of experience in the industrial chemical, pharmaceutical, consumer product industry. I've done risk assessments. I've looked at labels. I've helped people that live across the fence line. I've interpreted data for CEOs. business people down to the downstream customer handling the material.

My name is Anne Chappelle. I am a board-certified toxicologist with over 25 years of experience in the industrial chemical, pharmaceutical, consumer product industry. I've done risk assessments. I've looked at labels. I've helped people that live across the fence line. I've interpreted data for CEOs. business people down to the downstream customer handling the material.

And so my job really is to take this wealth of information that we have out there and kind of assemble it, figure out what's right, what is good science, Make sure it's transparent and translate it for the right audience member. So I am employed by a consulting company, but I also have some side things that I like to do.

And so my job really is to take this wealth of information that we have out there and kind of assemble it, figure out what's right, what is good science, Make sure it's transparent and translate it for the right audience member. So I am employed by a consulting company, but I also have some side things that I like to do.

I co-host of Adverse Reactions, which is a podcast by the Society of Toxicology. And I've also done some other things for like Wired Magazine or other podcasts. where they want somebody to help them understand what is the intent or just provide some context for what may be happening and use some of the skills that I have and my resources to help people understand what we're talking about. Perfect.

I co-host of Adverse Reactions, which is a podcast by the Society of Toxicology. And I've also done some other things for like Wired Magazine or other podcasts. where they want somebody to help them understand what is the intent or just provide some context for what may be happening and use some of the skills that I have and my resources to help people understand what we're talking about. Perfect.

It refers to damage to the brain, white matter, and it manifests itself as neurotoxicity. So what they've seen is that this tends to be more with females and people with liver insufficiencies. The liver issues can be typical of a drug abuser. We tend to think of the brain as being protected.

It refers to damage to the brain, white matter, and it manifests itself as neurotoxicity. So what they've seen is that this tends to be more with females and people with liver insufficiencies. The liver issues can be typical of a drug abuser. We tend to think of the brain as being protected.

You have a skull, and we all have this thing called a blood-brain barrier, which is something that protects our brain from being exposed to a number of different agents. So when you have certain substances, we often see that these agents that are really neurotoxic very potent, those that can cross into the brain, those have been associated with TL formation.

You have a skull, and we all have this thing called a blood-brain barrier, which is something that protects our brain from being exposed to a number of different agents. So when you have certain substances, we often see that these agents that are really neurotoxic very potent, those that can cross into the brain, those have been associated with TL formation.

The fact that jakes came on very quickly and progressed very quickly without going through the typical stages that you might see is a little bit unique. And a lot of times it's thought to be through a contaminant in the heroin.

The fact that jakes came on very quickly and progressed very quickly without going through the typical stages that you might see is a little bit unique. And a lot of times it's thought to be through a contaminant in the heroin.

This is an agent that has been associated with heroin-induced, chasing the dragon-induced TL. I mean, first of all, a lot of drugs are bad anyway, and you don't know what you're getting. But we've all heard of rat poison. Rat poison has been used to cut different drugs. We also have xylazine, Trank, that enhances like sedation effects. but it can cause a lot of wounds and tissue damage when used.

This is an agent that has been associated with heroin-induced, chasing the dragon-induced TL. I mean, first of all, a lot of drugs are bad anyway, and you don't know what you're getting. But we've all heard of rat poison. Rat poison has been used to cut different drugs. We also have xylazine, Trank, that enhances like sedation effects. but it can cause a lot of wounds and tissue damage when used.

Even baking soda, starches, and sugars, those can be used, not usually having a lot of adverse effects with those. But again, anytime you change a particular route of exposure, you've got an issue. So, for example, if you are inhaling baking soda, people think, oh, well, baking soda's safe. Well... It's safe when you ingest it in certain quantities.

Even baking soda, starches, and sugars, those can be used, not usually having a lot of adverse effects with those. But again, anytime you change a particular route of exposure, you've got an issue. So, for example, if you are inhaling baking soda, people think, oh, well, baking soda's safe. Well... It's safe when you ingest it in certain quantities.

It's safe when you make a cake with it or put it in the back of your fridge to absorb odors. But it isn't necessarily safe when you ingest part of it as a result of it being contaminated into your heroin. I think the point is that when you get a drug like heroin and you inhale it, you don't know what you're getting. So the fact that you are inhaling something

It's safe when you make a cake with it or put it in the back of your fridge to absorb odors. But it isn't necessarily safe when you ingest part of it as a result of it being contaminated into your heroin. I think the point is that when you get a drug like heroin and you inhale it, you don't know what you're getting. So the fact that you are inhaling something

right through the lungs, into the bloodstream, going straight to the brain. It is a very, I guess, effective delivery method because you avoid the stomach breaking things down. Because when you ingest something, you ingest it, it goes into your stomach. The acid in your stomach tends to break things down.

right through the lungs, into the bloodstream, going straight to the brain. It is a very, I guess, effective delivery method because you avoid the stomach breaking things down. Because when you ingest something, you ingest it, it goes into your stomach. The acid in your stomach tends to break things down.