Dr. Eric Topol

Yeah, so the glymphatics, not lymphatics, are the drainage system for our brain, which gets activated during deep sleep, the slow wave type of sleep. And that deep sleep is so essential. Unfortunately, as we get older, it gets decreased in amount of time. It tends to come in the earlier phases of sleep. Interestingly, not, you think deep that it would be late in the night, but it's not the case.

Yeah, so the glymphatics, not lymphatics, are the drainage system for our brain, which gets activated during deep sleep, the slow wave type of sleep. And that deep sleep is so essential. Unfortunately, as we get older, it gets decreased in amount of time. It tends to come in the earlier phases of sleep. Interestingly, not, you think deep that it would be late in the night, but it's not the case.

And we want to maximize that because that's the best way we get our brains refreshed and get rid of the stuff that's in our brain through the glymphatic system, which is relatively recent discovery that there's this elaborate system for basically pumping out these things toxins from our brain that accumulate each day.

And we want to maximize that because that's the best way we get our brains refreshed and get rid of the stuff that's in our brain through the glymphatic system, which is relatively recent discovery that there's this elaborate system for basically pumping out these things toxins from our brain that accumulate each day.

So sleep health is far more important to prevent these age-related diseases than we'd ever really recognized before.

So sleep health is far more important to prevent these age-related diseases than we'd ever really recognized before.

I think this is now the next frontier. It's so exciting to see this starting to take hold. If you have all of a person's data, and now we have tests that can predict Alzheimer's over 20 years before it happens, and all three of the big age-related diseases take at least 20 years to incubate,

I think this is now the next frontier. It's so exciting to see this starting to take hold. If you have all of a person's data, and now we have tests that can predict Alzheimer's over 20 years before it happens, and all three of the big age-related diseases take at least 20 years to incubate,

So if you have all of a person's data, and now that includes things like organ clocks from a blood sample, these new proteins like PTAU217 for Alzheimer's, and so-called epigenetic clocks, So the point here is that the science of aging has brought us all these new data types we never had before.

So if you have all of a person's data, and now that includes things like organ clocks from a blood sample, these new proteins like PTAU217 for Alzheimer's, and so-called epigenetic clocks, So the point here is that the science of aging has brought us all these new data types we never had before.

So we can take a person and say, you know, you're not at risk for any of these three major diseases, or we can say, pinpoint, you're at risk for this disease and say when, not just that you're at risk. And so that gives us the ability to, with AI, it requires multimodal AI because it's billions of data points, but that gives us the ability to start to

So we can take a person and say, you know, you're not at risk for any of these three major diseases, or we can say, pinpoint, you're at risk for this disease and say when, not just that you're at risk. And so that gives us the ability to, with AI, it requires multimodal AI because it's billions of data points, but that gives us the ability to start to

put a person under surveillance for that concern, that disease, and get all over it and prevent it. Something we've never been able to do in the history of medicine.

put a person under surveillance for that concern, that disease, and get all over it and prevent it. Something we've never been able to do in the history of medicine.

So this is something that's basically chasing our tails. We have all these new capabilities for promoting healthy aging and healthy longevity. But on the other hand, we're seeing increased exposure to air pollution, which is difficult to counter except for having air filtration in your home and being attentive to air quality.

So this is something that's basically chasing our tails. We have all these new capabilities for promoting healthy aging and healthy longevity. But on the other hand, we're seeing increased exposure to air pollution, which is difficult to counter except for having air filtration in your home and being attentive to air quality.

Then the next, of course, is the problem with microplastics that are getting to every part of our body and especially our heart arteries and our brain and implicated in conditions like heart attacks, strokes, and higher risk of dementia. So how do we get rid of plastics? That's hard. We can certainly reduce the intake of things that are in plastics.

Then the next, of course, is the problem with microplastics that are getting to every part of our body and especially our heart arteries and our brain and implicated in conditions like heart attacks, strokes, and higher risk of dementia. So how do we get rid of plastics? That's hard. We can certainly reduce the intake of things that are in plastics.

Don't microwave things that are in plastic containers. Don't use plastic any way we can avoid it. And that, of course, also applies to forever chemicals that are pervasive in so many things where we unfortunately, Dana, don't have

Don't microwave things that are in plastic containers. Don't use plastic any way we can avoid it. And that, of course, also applies to forever chemicals that are pervasive in so many things where we unfortunately, Dana, don't have