Dr. Matthew B. (Matt) (likely the presenter) - Unknown

You want to feel the burn in your quads.

So a little out of breath.

Feeling good?

Increase the blood flow to the brain.

But more importantly, glute forward transporters.

OK.

So we're going to shift gears, and we're going to talk a little bit about circadian meal timing.

All right.

Okay, so as everybody here knows about circadian rhythm, we're all diurnal creatures here, more active during the day, less active in the evening, right?

Our metabolism is also on a circadian rhythm.

We are more insulin sensitive earlier in the day and later in the evening, less insulin sensitive.

Part of that

So let me talk about a study that I think is pretty telling in terms of insulin sensitivity and glucose regulation throughout the day.

So participants were given the same exact meals in the morning, in the afternoon, or in the evening.

So same macronutrient composition, same calorie content, everything the same.

And participants were much more insulin sensitive in their first meal, given in the morning, compared to their evening meal.

And I think part of this has to do with our circadian rhythm and, as we get later in the day, melatonin.

So back in the early 2000s, about 2009, a lot of studies started coming out in the genetics world where a certain variation in the melatonin receptor 1B was identified to be a pretty high risk factor for developing type 2 diabetes and for having basically insulin dysregulation.

So people were not producing insulin correctly.

And it was very perplexing to scientists at the time because melatonin was thought to be just this hormone that is produced by the pineal gland that is regulating our sleep.