Dr. Matthew B. (Matt) (likely the presenter) - Unknown

But generally speaking, I think just aligning your meals with your circadian rhythm, it makes sense.

When you think about the role of melatonin in quieting down our brain and also our pancreas, it makes a lot of sense why you don't want to be eating late at night.

So just as I think an aside here, having glucose levels in the normal range, but on the high normal range, so high normal glucose.

was associated in UK biobank data with higher incidence of atrophy in the hippocampus, so the part of the brain involved in learning and memory.

So people that just had higher than, they were on the high end of normal, had more atrophy in their hippocampus than people on the low end of normal.

So this is in the absence of any clinical type 2 diabetes, really sort of highlighting the importance of everyone considering their metabolic health, even if you don't have type 2 diabetes, even if you're not pre-diabetic.

You want to make sure that your glucose regulation is the best it can be.

Circadian misalignment.

Now, so many of you may have come from, like me, the West Coast, or perhaps Europe, and you're,

out of sync with your circadian rhythm.

So circadian misalignment refers to when your natural internal clock is out of sync based on a behavioral pattern.

So this is very common with jet lag.

It's very common in shift workers who are up in the night, in the evening, working and eating.

It's also very common in people with erratic sleep behaviors.

So there's been studies done where people, our participants, they're circadian misaligned.

So they're out of sync.

So basically their sleep and meals are shifted by about 12 hours.

And when that happens, people have about a 6% increase in their glucose.

They make 22% more insulin.

They have decreased leptin levels, so that's the hormone involved in being satiated.