Dr. Nathan Bryan

I was exposed to COVID and I've never had COVID.

I never took nicotine.

Well, I think for us, what we recognize is that the spike protein binds to the ACE2 receptor.

And so in people who are nitric oxide deficient, there's an upregulation of the ACE2 receptor.

So there's more binding sites for the spike protein.

People who take nitric oxide like me, who are nitric oxide replete, the ACE2 receptor is downregulated.

So we may be exposed to COVID or the spike protein, but there's no receptor for it to bind to.

So we become resistant to viral infections.

Wow.

That's right.

And understanding the signaling aspects and downregulation of adhesion molecules, decreasing inflammation, oxidative stress, and immune dysfunction, and allowing the immune system to go.

Because we've known since 2005 that nitric oxide prevents coronavirus replication.

That was SARS-CoV-1.

SARS-CoV-2 or COVID-19 is basically the same mechanism.

So it prevents viral replication, and it's how our innate immune system works, similar to bacterial infections.

We get a bacterial infection, our immune system is mobilizing.

We generate nitric oxide.

It binds to the iron sulfur centers of the bacteria, shuts down the respiration, and kills it.

But if you can't make nitric oxide, if you don't have a good immune system, a good cardiovascular system,

The bacteria or the viruses become immune to the cardiovascular system because poorly vascularized tissues are more prone to infections.