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Dr. Satchin Panda

👤 Person
1590 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

That means that's broken down and that increases blood sugar level and the pancreas has to adjust that sugar by producing insulin. And pancreas does have a circadian clock. So that means it actually doesn't produce enough insulin late at night. So that's one. And then the second thing is the sleep hormone melatonin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

That means that's broken down and that increases blood sugar level and the pancreas has to adjust that sugar by producing insulin. And pancreas does have a circadian clock. So that means it actually doesn't produce enough insulin late at night. So that's one. And then the second thing is the sleep hormone melatonin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

That means that's broken down and that increases blood sugar level and the pancreas has to adjust that sugar by producing insulin. And pancreas does have a circadian clock. So that means it actually doesn't produce enough insulin late at night. So that's one. And then the second thing is the sleep hormone melatonin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

that goes up at night, and that's why people who have sleep problems, they think that they can sleep well by taking extra melatonin, and I'll get to that, but melatonin actually has another brick on insulin production, because melatonin makes the pancreas less sensitive to glucose level in our blood, so the pancreas cannot sense accurately how much glucose is in the blood, so it cannot produce or release enough insulin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

that goes up at night, and that's why people who have sleep problems, they think that they can sleep well by taking extra melatonin, and I'll get to that, but melatonin actually has another brick on insulin production, because melatonin makes the pancreas less sensitive to glucose level in our blood, so the pancreas cannot sense accurately how much glucose is in the blood, so it cannot produce or release enough insulin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

that goes up at night, and that's why people who have sleep problems, they think that they can sleep well by taking extra melatonin, and I'll get to that, but melatonin actually has another brick on insulin production, because melatonin makes the pancreas less sensitive to glucose level in our blood, so the pancreas cannot sense accurately how much glucose is in the blood, so it cannot produce or release enough insulin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So now you combine these two, what happens is when we eat late at night or very close to bedtime, then there are at least two or maybe even more things that are playing against digesting and absorbing that glucose correctly. One is insulin production itself has slowed down.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So now you combine these two, what happens is when we eat late at night or very close to bedtime, then there are at least two or maybe even more things that are playing against digesting and absorbing that glucose correctly. One is insulin production itself has slowed down.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So now you combine these two, what happens is when we eat late at night or very close to bedtime, then there are at least two or maybe even more things that are playing against digesting and absorbing that glucose correctly. One is insulin production itself has slowed down.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

And second, if there is melatonin that's rising, and actually two hours to three hours before our habitual bedtime, our pineal gland starts to produce melatonin. So that means within two to three hours before bedtime, if we eat, then that melatonin can inhibit, can desensitize the pancreas so that it's not producing enough insulin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

And second, if there is melatonin that's rising, and actually two hours to three hours before our habitual bedtime, our pineal gland starts to produce melatonin. So that means within two to three hours before bedtime, if we eat, then that melatonin can inhibit, can desensitize the pancreas so that it's not producing enough insulin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

And second, if there is melatonin that's rising, and actually two hours to three hours before our habitual bedtime, our pineal gland starts to produce melatonin. So that means within two to three hours before bedtime, if we eat, then that melatonin can inhibit, can desensitize the pancreas so that it's not producing enough insulin.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So these two can work together to first thing that will happen is you might have higher level of blood glucose level. And this is something that has been observed since 1970s. Even, in fact, endocrinologist would take healthy people and fast them for 10 to 12 hours and then give them a bolus of glucose either in the morning or after 10 to 12 hours of fasting.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So these two can work together to first thing that will happen is you might have higher level of blood glucose level. And this is something that has been observed since 1970s. Even, in fact, endocrinologist would take healthy people and fast them for 10 to 12 hours and then give them a bolus of glucose either in the morning or after 10 to 12 hours of fasting.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So these two can work together to first thing that will happen is you might have higher level of blood glucose level. And this is something that has been observed since 1970s. Even, in fact, endocrinologist would take healthy people and fast them for 10 to 12 hours and then give them a bolus of glucose either in the morning or after 10 to 12 hours of fasting.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

the same bolus of glucose or sugar in the evening. What they found was the same healthy person may be diagnosed healthy in the morning, but may be diagnosed as diabetic because this person's blood glucose goes pretty high and doesn't come down easily.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

the same bolus of glucose or sugar in the evening. What they found was the same healthy person may be diagnosed healthy in the morning, but may be diagnosed as diabetic because this person's blood glucose goes pretty high and doesn't come down easily.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

the same bolus of glucose or sugar in the evening. What they found was the same healthy person may be diagnosed healthy in the morning, but may be diagnosed as diabetic because this person's blood glucose goes pretty high and doesn't come down easily.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So this is another example where people who are thinking that they can get away with food at night, although we are not walking around with continuous glucose monitor, all of us, but some of them, And this is a common theme that we are finding.

Dhru Purohit Show
Supercharge Your Sleep and Improve Your Longevity Using the Power of Intermittent Fasting & Circadian Biology (Rebroadcast)

So this is another example where people who are thinking that they can get away with food at night, although we are not walking around with continuous glucose monitor, all of us, but some of them, And this is a common theme that we are finding.