Hosseini Manji

Why is depression so hard to treat? Yeah, I think that's a very good question. So in contrast to some what we might call physical illnesses, illnesses of the brain and the mind are less well understood.

Why is depression so hard to treat? Yeah, I think that's a very good question. So in contrast to some what we might call physical illnesses, illnesses of the brain and the mind are less well understood.

Why is depression so hard to treat? Yeah, I think that's a very good question. So in contrast to some what we might call physical illnesses, illnesses of the brain and the mind are less well understood.

Depression is unfortunately one of the most disabling conditions there is. And although we've had a number of treatments, many people don't respond to them. So there's a real need to come up with improved treatments.

Depression is unfortunately one of the most disabling conditions there is. And although we've had a number of treatments, many people don't respond to them. So there's a real need to come up with improved treatments.

Depression is unfortunately one of the most disabling conditions there is. And although we've had a number of treatments, many people don't respond to them. So there's a real need to come up with improved treatments.

One of the things that sometimes surprises people is that almost all our existing antidepressants, even when they work, take about four to six weeks to work. And that led many people, including myself, to think maybe we're hitting the wrong target, that just increasing levels of serotonin is a starting point.

One of the things that sometimes surprises people is that almost all our existing antidepressants, even when they work, take about four to six weeks to work. And that led many people, including myself, to think maybe we're hitting the wrong target, that just increasing levels of serotonin is a starting point.

One of the things that sometimes surprises people is that almost all our existing antidepressants, even when they work, take about four to six weeks to work. And that led many people, including myself, to think maybe we're hitting the wrong target, that just increasing levels of serotonin is a starting point.

Ultimately, you need to bring about other changes, which results in people getting better.

Ultimately, you need to bring about other changes, which results in people getting better.

Ultimately, you need to bring about other changes, which results in people getting better.

So I was involved in some of the earlier studies using intravenous ketamine, and those studies really showed remarkable effects. So we were looking at patients who are sometimes called treatment-resistant depressed patients, And in those patients, we saw that within 24 hours, 70% of those patients were classified as responders.

So I was involved in some of the earlier studies using intravenous ketamine, and those studies really showed remarkable effects. So we were looking at patients who are sometimes called treatment-resistant depressed patients, And in those patients, we saw that within 24 hours, 70% of those patients were classified as responders.

So I was involved in some of the earlier studies using intravenous ketamine, and those studies really showed remarkable effects. So we were looking at patients who are sometimes called treatment-resistant depressed patients, And in those patients, we saw that within 24 hours, 70% of those patients were classified as responders.

And what was interesting was that although the drug, the ketamine, is gone from your system within two to four hours, people remained well for at least four days.

And what was interesting was that although the drug, the ketamine, is gone from your system within two to four hours, people remained well for at least four days.

And what was interesting was that although the drug, the ketamine, is gone from your system within two to four hours, people remained well for at least four days.

When I first brought up the idea, I think understandably people had some reservations because ketamine has sometimes been used as a club drug. So I had to really sort of walk through a lot of the reasons why I thought this would be successful.

When I first brought up the idea, I think understandably people had some reservations because ketamine has sometimes been used as a club drug. So I had to really sort of walk through a lot of the reasons why I thought this would be successful.