Jen Scheinman
Appearances
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
There are some biomarkers that people are using, but there really isn't a great go-to-your-doctor test for mitochondrial dysfunction. Now, in a lab setting, when our scientific arm is studying mitochondrial dysfunction, and when we talked about the hallmarks of aging and all of that, there are some fantastic clinical labs that you would use in a study setting.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So for example, usually it's done with a muscle biopsy where you're taking a bit of muscle tissue and then you're looking under, you know, very high tech imaging to look at mitochondrial function. You're measuring, you know, gene markers of mitochondrial function and other, you know,
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
There are markers that are showing that free fatty acid oxidation is happening or amino acid oxidation is happening. But there just isn't like for you and me to go to our doctor and say, hey, can you test my mitochondrial function? There are some newer direct-to-consumer or practitioner tests that are emerging on the marketplace.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I'm not sure, you know, and our research team is like full of scientists that have been studying mitochondrial health for their entire career. Like, I'm not sure those tests are there yet, but I think they're an interesting tool for people to have in their back pocket. You know, would I put all of my weight on them? Not yet.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So that's a frustrating answer in the sense that there's just not a good way to test your mitochondrial function. I think how you feel is one good way, right? Like fatigue, not bouncing back from workouts the way that you used to, you know, brain fog. Those are great indicators.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
You know, things like VO2 max, that also would be a wonderful indicator of, you know, but they're all sort of like biomarkers and they're just not necessarily direct measurements of urolithinase. So those would be ways for you to kind of tell like this is helping, right? Like I am noticing how I feel.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And that's what our research has shown is like first we started with these muscle biopsies and showed that after four weeks of placebo, 500 milligrams or 1,000 milligrams of urolipin A, we saw that both the 500 and 1,000 milligrams of urolipin A was in fact inducing this mitochondrial turnover and that we were seeing these robust improvements in mitochondrial health.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so that's, you know, and that study, we can share these, all these studies in the show notes. Those are all our studies are published in really high and top tier medical journals. And so people can go and read these results for themselves.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. So, you know, your 30s are kind of this sweet spot of aging where everything just starts to decline.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
You know, I always joked before I actually even really like started studying this in depth. I was like, my warranty went out when I turned like 33. Right. It was just like, you know, like I could bounce back from anything. And then all of a sudden I was like, what? Well, I like tweak my back. And instead of like the next day being OK, I'm like, oh, that's not to cut you off.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So, you know, so I think in sort of like the general pop, right, like this, your third decade is when everything like men, it's testosterone, you know, women, our hormones still hang in on that. But they're starting, you know, like by your mid 30s, you know, 40s for sure. We're starting to see, you know, we start to enter perimenopause, muscle decline starts to happen.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But I think, you know, with people who maybe lived a very inactive lifestyle, like that might be happening earlier. If you're eating a junk food diet, your mitochondria are going to be sensitive to that. Right. And so there's not necessarily a hard and fast rule that you're great until you're 30. So I think if you're also doing everything right. Maybe it's a little bit later.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
You know, so I think things like tools like Urolithin-A, just like, you know, fitness and nutrition, like those are things that you want to start earlier, the better, and hopefully are going to help to slow down and cushion some of the more dramatic things that happen as you start getting into your 30s, 40s and later. But not to say that if you are in your 70s and just want to start now, like...
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
that's not too late either, right? That's definitely, you know, it's never too late. So, but yeah, I mean, people, there are definitely, you know, things like mold exposure and Lyme disease and chronic fatigue syndrome and all of those things will also damage your mitochondria.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So if you are a younger person and you're suffering with that, then you're having some degree of mitochondrial dysfunction. But for just sort of general pop, yeah, your 30s is probably when things are starting to starting to, your warranty is getting towards its end.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. So we haven't
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
studied it and people under 18 so i think you know anyone who's sort of still developmentally you know going through the thing let's leave that for another conversation but you're absolutely right for younger populations um so first of all if you are an athlete especially like uh you know someone like you who's training super hard and intense more than just like for general fitness right or you're a professional athlete and your career depends on your body right
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
you are actually exhibiting mitochondrial dysfunction despite the fact that you are... Really? Yeah. It's almost like a Goldilocks effect where it could be too much too, right? And so we do see that there are benefits in younger athletes using it. And we have a number of professional athletes that take it and what we've seen.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So our studies first really started looking at older sedentary population, but because we know, right, the mitochondria They're producing like a ton of energy for you to do your 100, 150 minutes of cardio a day, right?
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
That is an incredible amount of energy all coming from your mitochondria, right? So they're getting used... a lot more than like me who is just doing my like 30 minutes of cardio and my like 30 minutes of weight. So what the study, so one study, this is a really interesting study that just got published that was in younger population. Actually, Timeline didn't have anything to do with this study.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
They did use MitoPure. They purchased MitoPure, but it was the Beijing Sports Institute did it like completely independent of us. And they looked at, I believe it was average age of like 24. So young college trained, strength trained athletes. And they found these similar results in muscle strength and muscle endurance that we saw even in older adults.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And these are people who are really like they were, you know, working on a training regimen. They were, you know, they were, again, just not your like average person that goes to the gym. They were strength trained athletes. There's another study that is wrapping up that's not published that was also in now endurance. So not necessarily strength train.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
These were Olympic trained athletes who runners, distance runners, and they went to training camp. So everything that was being accounted for their training workout and their diet, and they were randomized to either urolithin A or, um, And the data is still being analyzed there. So I don't have like a strong claim that I can say until this is published data.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But it seems the story there is really in recovery, helping. And that's something we hear all the time is, you know, after I take this, like I don't really get sore at the gym. Like an example for me personally, I'm not a big runner. I mean, I've been really focused on strength lately. So like my cardio has taken a little bit of a hit, sadly.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I got roped into doing a, sorry, what I thought was a 5K workout.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
trail run and I got there and found out it was a five mile trail run um a little different and it was super hilly and outside and I was like oh man what did I sign myself up for and and I didn't do great on the run like this isn't a miracle where it like made me like be able to do something I wasn't trained for I definitely didn't do that but I really thought the next day like I was going to be so sore and so tanked and I like woke up the next day and I felt amazing like
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I was like, wow, that's incredible. And I felt that very often that I do like a super hard workout or something that's different than what I normally do. And just think at my age, like I'm almost 50, like I don't really feel that tomorrow. And I don't. And so the science, I think, will be backing that up very soon. Yeah. which is really interesting.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, I mean, I think so, right? That the data, you know, when we talk about the clinical studies, right, a lot of it is skews a little towards the older person. There's some new data that is coming out around younger people. So, but we just think about like the biology of what's happening.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Like we are living in a sort of toxic soup environment these days where our mitochondria are getting damaged. I, you know, I think it's a very specific type of person who eats perfectly and exercises perfectly every day, right? And sleeps every day. who is not leading like some sort of high stress life.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So I do think that there is benefit the earlier that you start with, again, like all lifestyle things, right? Like why wait until something is, you know, until that warranty starts to run out, right? Why, you know, you don't not do oil changes in your car until the warranty runs out, right? There are things that you do to help make sure that that car is going to be in its best working order.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Long past the day that the warranty happens. And that's how you should treat your body, right? The things that you want to be doing as a younger person. And I think, you know, we're starting to see that with like this, you know, Chinese sports study that there are benefits even in younger people taking things like urolithin A.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. You know, and I was just working on something else this morning and I know this statistic, but every time I see it, it like shocks me. Less than a quarter of U.S. adults meet the guidelines for physical activity, for cardio and strength. Right. And so... Yeah. And so we got to start with changing that for sure. Right.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But I think like we're also talking to a very specific population when we also only say like, hey, you who exercise, this might help you. Right.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
The vast majority of people in the US. And so even if your audience are people who are doing a lot of things to take care of their health, I bet they have loved ones that are not always right. Yeah. And I think that's one of the things that I found so remarkable when I first started digging into the science around urolithin A was, wow, this is having an impact in people who aren't exercising.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. And that is huge, right? Because there are so many reasons why people don't exercise, right? Like, you know, I think most people want to do some sort of exercise. But, you know, as a career dietitian, I know how hard behavior change is and getting people to stick with it, right? They start a program and they stick with it for a couple of months and then they fall off and
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so the intention is there. There's a million reasons why it doesn't stick. But the thought that you can get some benefit from a dietary supplement to maybe help bridge that gap. Or if you have an injury and you can't get to the gym, there are a lot of things. And that was just what was so interesting to me was that we saw these benefits in strength, for example.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
These were in middle-aged adults who took, like you, 500 milligrams. And over the course of four months, We saw this significant, robust improvement in muscle strength, you know, after just four months. And we didn't change diet. We didn't change exercise. So, you know, and I think one of the reasons people struggle also to exercise is they don't have the energy to do it.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Like it's almost this like paradoxical thing where like, you know, You got to like figure out how to have enough energy to work out. And then when you work out, you do have more energy. But it feels like a really big boulder to lift when you just are fatigued and don't have the energy to like cook a healthy meal and to get to the gym.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so what if there there was something like Mito Pure that could kind of help move you along and you could start to feel like you have a little bit more energy and a little bit more like yourself and start to. revitalize the energy centers that are happening in your muscle cells. And then you can maybe get yourself to the gym.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And then the power of the gym is really like, that's really what is the exercise and diet. I've said a million times, like nothing's going to change that. You've got to do that.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But it's really nice to know that there are tools out there that can help support all that hard work that you're doing, or maybe get you to a place where you feel like you have that, just that slightest bit more edge to get you to the gym to cook a healthy meal.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So let's just first address diet and urolithin A, and then we can kind of talk about mitochondrial health. So, you know, it kind of doesn't matter, like, what you eat in order to get your, like, if you're taking a dietary supplement of urolithin A, if you're taking MitoPure, like, you... You know, it's going to work regardless of how you're eating.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Now, of course, how you're eating, though, is like the foundation of like your good health, right? So like a healthier diet with urolithin A is going to be a much different experience than just like urolithin A on its own.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So you're not going to like play around with how your body like digest and absorb it, whether you're eating carbs or whether you're eating a high fat diet, like your body will still absorb it and utilize it. But of course, your mitochondria, like remember, we talked about like the raw materials are the food that you eat.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. Well, before I do that, I just thank you for sharing some of your experience with the supplement industry. And we have a very similar pathway in the sense that I've been in the wellness industry myself for, I think the bio I had you read said almost 20 years, but it's actually probably almost 30 years.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so the quality of what you start with is going to play a role in the type of energy that comes out. And the sort of other ingredients that go into producing ATP are things like the vitamins, the polyphenols, the nutrients that you get through your food. So I mean, there is a lot of like You've got to be carnivore diet. You've got to be vegan diet.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I think everybody, it's kind of almost become like a religion at this point of what's the best diet. But there are certain things that are absolutely going to play a role into your mitochondria. You've got to make sure that you're getting all the key nutrients, things like CoQ10, B vitamins, polyphenols.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Besides, we talked about the oligotannins are the polyphenols that your gut will turn into your olefin A, but there's other polyphenols that are protective on your mitochondria. So things like what are in things like green tea, right? They're olive oil, right? A lot of these polyphenols are going to be protective of your mitochondria.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
My personal belief, right, is a lot goes into food and longevity and diet, right? And like when we look at like
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
the long-lived communities around the world right like they're eating very sort of traditional types of diets that are full of plant food that are full of whole food they're not eating a lot of like processed things that's really i think what you know whether i think there's like a therapeutic reason why some people are going to do great on a keto diet i think there's a lot of
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
People have philosophical reasons around not wanting to eat meat. I think there are places for all of that for you as an individual to decide what's the right diet for you. I personally, I don't feel great. I have tried a keto diet millions of times. I've tried to get through the keto flu. I just don't feel great on a keto diet. I think that my body and I think that we all have different genetics.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I think my body just does better with some carb, but I also have to eat high quality carbohydrate. Like I don't eat sugar and processed carbs. I'm eating things like sweet potato and whole grains. I also feel much better when I eat animal protein, right? I personally need animal protein in my diet. I don't feel well when I am not eating that.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I think there's a lot of individuality here on people's you know belief systems and individual biology and just how you like to eat like let's not forget how you enjoy like food is such a part of pleasure for most people and I personally believe like it's a social it's a cultural it's a pleasure thing you know like if somebody told me like you could never eat that again like I don't know.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I joined the team at Timeline, I think the same reason why you and so many of the other amazing educators and partners that we have is because They look at the science and they look at the transparency in, you know, Mito Pure specifically, the branded urolithin A supplement. And it's so different than what's happening in the supplement industry. And we can get into that later.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
That's not the world. I don't want to live in that kind of world. And again, these are all very individual decisions and choices. So I don't necessarily like to say one thing is better than another, but there are certain things we know for sure, like high fructose corn syrup is not going to be good for your mitochondria. Like inflammatory fats, not going to be great for your mitochondria.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Polyphenols, vitamins, minerals, they're going to be great for your mitochondria. Omega-3 fatty acids, like all of these things are going to be really helpful in making sure that your mitochondria work and function correctly.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, walnuts are a great nut in terms of omega. I think they're actually the highest omega-3 nut that is out there. I snack on walnuts all the time. Yeah, me too. Yeah, seeds like chia seeds, hemp seeds. Those are going to be great. Your polyphenols, I think of kind of like eating the rainbow, right? Like you want to try and have as much variety in what you're eating.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So you want to have your green leafy vegetables. You want to have your red berries and tomatoes. You want to have oranges, orange peppers, orange, you know, carrots. That's going to really ensure because polyphenols will do things besides just like your mitochondria, right? They're like powerful anti-inflammatory. They, you know, they help with, you know, cancer prevention.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So you want to be really eating a lot of variety, eating from different, you know, aspects of the rainbow. I have recently been reading some research and this like sounds alarming to some people when they first hear it, but it's actually not as crazy as it is that you want to try and engage in eating 30 different plant foods a week.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
so wow yeah 30 different plant foods but what counts are as plants it's not don't just think vegetables and fruits right so things that count as plants are going to be like your whole grains your beans your nuts your seeds and your herbs and your spices so herbs and spices are like potent they're like a pharmacy basically level of you know polyphenols antioxidants and other like that's why like turmeric like right think about that right it's such a huge powerful antioxidant and people are taking that as like
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
in supplement form but all of our herbs and spices are just powerhouses of nutrients and a little bit goes a long way so teas like there's a lot of ways so 30 doesn't need to be like Oh, my God, that's crazy.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Like if you eat a big salad that has like tomatoes and carrots and maybe you throw some like seeds in there and some chickpeas and some olives, like, boom, you've just gotten probably like seven to five of your daily there. Right. And then you like have dinner and you make something with a tomato sauce that has basil and onions and garlic and tomatoes and maybe you throw in some like peppers.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Boom, you've just gotten like another five to 10. Right. So it's not as like crazy as it should be. But that's an interesting rule of thumb. I've recently been reading some research about and kind of a nice sort of target for people's 30 different plants.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But I think that's just really important for your audience to kind of understand is like the type of research we're going to talk about today is not everyday research that supplement companies do on the regular. And this is really raising the bar on the way brands should be really like marketed and thought. putting supplements together.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, I mean, and Gundry probably does a million time better job than even I could do, right? But I think we are just starting to, as much as we know, we're still just beginning to understand the critical importance of the gut.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And it's interesting because I also say that like, where mitochondrial health is today, the concept of it and like the awareness in the public is almost like where gut health was like 15 years ago. So if your audience is also like, I don't want to learn more about the mitochondria.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Like, guys, I think you're in for a ride because I think like just how gut health 15 years ago, people were like, I got to care about my gut. And now like we talk about it every day, like mitochondria is the same way. Like in five to 10 years, the science is there. It's just the awareness isn't there yet. And so it's the wave. I hate to call it a trend, but it is like the next wellness wave. Yeah.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So your gut, I mean, your gut is really like where the outside meets your inside, if you think about that, right? I mean, that's where you take in food as a foreign substance. Your body digests, absorbs it, and takes everything that it needs and puts it into action in your body, but then also comes in contact with a lot of things like we don't want in our body, and then we get rid of it.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And there's just so much through stress, medications, our lifestyle, and obviously the food that we eat that is really... wreaking havoc on our gut. And I think like this concept about urolithin A, I think is just a great sort of segue into that, right? Like we probably evolved to have this very diverse gut microbiome where we had urolithin A in our bloodstream in high concentrations all the time.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And we have now engineered our way into an unhealthy gut where we don't make a lot of urolithin A. And in fact, we've studied populations and really only about 30 to 40 percent of the population has the right gut microbiome to make urolithin A. And even for those who have the right gut microbiome, you have to drink
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
six cups of pomegranate juice a day to get the same effect as which like you know I would never recommend that to anyone and I think the reason why there's this like stark difference is because we used to have this much more diverse gut microbiome that was you know robust and we had a much more diverse diet where we're eating a lot of polyphenols and things that were helping our gut microbiome.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
With that, let's just start with what, you know, it's a mouthful, urolithin A, right? That's probably most people have never really heard that word before. And if you haven't, you're not alone. I mean, as a dietician, really only about three or four years ago, I learned what urolithin A was. And that's not because it's newly discovered. It has been
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I don't think we even know all the things that our gut does for us, right? I mean, it regulates everything. It's part of your immune system. It's actually like there's a superhighway from your gut to your brain and the vagus nerve. I mean, there is You know, I've seen some preliminary research that there's even a gut mitochondrial pathway or access.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
There's just like we hear the gut brain access. You know, I think Dr. Gabrielle Lyon talks about like the gut muscle access. Like we are learning that the gut is tied to just about everything in our body. I mean, your gut and your skin, like they go hand in hand, too.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
It is, you know, and whether it's through the actual like epithelial, the actual lining of the gut or it's through the microbiome or a combination of both and the, you know, the inflammation that's happening in the gut and, you know, the immune regulation, like I think we still need to figure out like. how, but we know that there's a link to all of this for sure.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
You know, so, you know, good gut means good muscle means good brain means good mitochondria, you know, means all the things.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, no, I absolutely. I mean, I think, you know, and I think, you know, sometimes I think people tend to like overcomplicate things in the sense of like, you got to focus on your God and you've got to focus on your mitochondria and you've got to focus on this. But like,
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
When you're focusing on yourself as sort of like in this holistic way of like, I'm going to eat clean and nutrient dense food and I'm going to do exercise that's like appropriate and in the right times, you know, and frequencies. And I'm going to focus on my sleep and my mental health. Like you are going to be working on your gut and you are going to be working on your mitochondria.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And of course, there are like certain things, right? Like urolithin A, which is really going to be strategically helping to build up your mitochondria. Or you might be taking, you know, a specific...
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
type of fiber that's going to help your gut so like while there are little pieces here and there that you might like target to really like take one system to the next level like it doesn't need to be over complicated like you if you're if you're doing all the right things like you're doing all the right things
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
100%.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Not, not, not dietician approved, at least not by this one.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
studied extensively for over 15 years, there just wasn't really a branded supplement on the market with marketing dollars behind it to start talking about it. But there's some incredible research that we'll talk about. So let's start with just what it is. Where do you find it in nature? So a lot of times we're talking about supplements and we're talking about nutrients.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. So our ATLAS trial, and that's just sort of like a little fun acronym that we gave for this trial. That was a study that was done in middle-aged adults. So I think the average age there was they were probably around like 40 to 60, 64. And this one was really designed to be looking at muscle strength. So what we did and we took it, you know, the patient population was
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I think of them as sort of like your average American. They'd like a BMI of like 29, which is, you know, in the overweight category. They were, you know, just like we didn't necessarily exclude them if they were on blood pressure medicine or like statins or, you know, things for glucose control.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Again, like if you have a BMI of 29, chances are you have some sort of metabolic dysfunction that's starting to happen there. And this group was randomized to either placebo 500 or 1,000 milligrams of urolithin A. It was a 16-week trial, so four months.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And what we found there after four months was that we had the significant improvement at 12% improvement of hamstring, specifically hamstring muscle strength at the end of that study in, you know, we didn't change their diet, we didn't change their exercise. So it meant that they were sedentary through the whole study, which is we were kind of talking about.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
before, I think is really remarkable that you can still see benefits, strength benefits. You know, you work, you know, in the fitness industry, like, you know, like to see changes like that for somebody who's not exercising, you don't see that very often. So you don't at all. Yeah, yeah. Yeah.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And then some of the other interesting things that changed, which weren't necessarily statistically significant, but were sort of like trending towards that were these improvements in, you know, the marker VO2 max, for example, which is really becoming like a almost like a longevity biomarker, right? And so we saw some improvements in that as well.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And, you know, I think the thought is like if these studies went longer, like would we see with these changes actually become statistically significant? So to me, I think that is really, really compelling evidence for the benefit of something like urolithin A for people like, you know, especially when we think in midlife,
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
what's happening there right like women specifically are starting to go through perimenopause where we are starting to lose our muscle due to estrogen loss like men are starting to go through andropause like they're also you know while it's not quite as drastic a change like their muscle is being impacted by that you know we talked a little bit about testosterone earlier so while we weren't really like looking specifically in that study on like hormonal changes and and all of that i think it's you know this midlife area is when we are really starting to see
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
decline starting to happen. And so the fact that in the sedentary population, you do see this robust improvement in muscle strength with just 500 milligrams, I think is really pretty significant and meaningful in terms of just like real life, right? Like often I get like, so cool. Who cares about my mitochondria? Like, what does that really mean for me? Like, what am I going to feel?
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I think that's it, right? Is that this potential improvement in muscle strength is important.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
We're talking about things that we find in food. And your eliminate is a little bit different. It's not directly found in the food we eat. Instead, we are relying on our gut to make it for us. Right. And I'm sure your audience, like any other health savvy kind of consumer out there, knows the critical importance of the gut. Right. Right.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So interestingly, and I, you know, as I'm sort of starting to go through perimenopause, I've been sort of looking at like the role of hormones and mitochondria. And so this was something I recently learned, right? Like that your mitochondria actually have estrogen receptors, right? And your mitochondria do play a role. Yeah. And your mitochondria do play a role in... hormone production.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So in women particularly, the fastest aging organ in our body is our ovaries. And egg production is highly, highly dependent on energy from the mitochondria. So I think there's a lot of stuff that is in
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
preclinical data sort of linking hormones to mitochondria as terms of like in clinical data, like meaning actually in humans, there may be, I'm just not familiar with it, but there is definitely a link between hormones and, you know, and mitochondrial function.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I think it's just really, you know, as I said, like we're on this like cusp of really the like mitochondrial function being the newest, like, thing to talk about in the wellness world. And I think as more data comes out in humans, we will start really understanding more and more about the role like mitochondrial play in everything.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So I think that one of the things that's really interesting about our studies that we have done, so unfortunately, women in general, and particularly perimenopausal and menopausal women, have been sort of notoriously excluded from a lot of research studies.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Our studies had actually like, I think, 60% in one and it might have been even more women. So that study that we just talked about, that Atlas study that was 45 to 60 years old, had a majority of women in there.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so while we weren't really like collecting data on menopause or looking at that, I think, again, it's safe to assume if you are 45 to 60, you're either perimenopausal or you probably postmenopausal. And we saw that it worked. in that patient group. So I think that's fantastic news. And we think about what's happening to the muscles as we start to lose estrogen.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, I think that the more that I'm understanding the biology of it, I think it is like the perfect supplement for women who are going through perimenopause or postmenopausal. The other thing which we haven't even talked about yet is you can use urolithin A mitopure topically. There is a topical formulation. And again, I speak for myself like
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And one of the reasons our gut is so important is we have these microbes, these bacteria that live inside our gut. And one of the things that they do is they create a molecule. It's called a postbiotic. Basically, like a metabolite of things we can't digest and absorb. So I like to say often that our gut microbiome, we give room and board and they pay us back. So.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
As you start going through perimenopause, it almost feels like you wake up one day and literally like your face is just sagging, like you don't even know how that happened, right? And part of that is the estrogen loss that's impacting collagen production.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so what we've seen with topical use of urolithin A is that when you use urolithin A topically, the genes that turn on collagen organization and assembly, they're all upregulated and we start to see reduction in fine lines and wrinkles. So that is like even a whole nother place for women who are going through perimenopause to think about like, urolithin A in a topical application as well.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So yeah, I think there is definitely for men, for women, as we are aging, this is just sort of, to me, feels like a no-brainer because it is really getting to that hallmark of why we age. Mitochondrial dysfunction is happening.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. So it's using the same MitoPure technology that would be in the dietary supplement. It's just staying localized and very potent in the skin. So while this is a completely different mechanism of action, I think people are very familiar with the fact that like you eat vitamin C, right? And you get a benefit, but you also apply vitamin C topically and you get a potent skin benefit.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So you can think of it in that sense, but it's still targeting the same aging pathways. It is still causing the mitochondria in your skin to be able to rejuvenate. And so when you have healthier mitochondria, you basically have a skin cell that's acting in a more youthful way.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So that means that you're going to, you know, and what we see is, you know, they mentioned already about like collagen and what we see in just two weeks is visible signs of aging are reduced. And then when you take that out to eight weeks and do these like high tap imaging, we start to see similar to retinols, a similar type of wrinkle reduction. So wrinkle volume, wrinkle depth is reduced.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
The thing though, that's really unique is like, a lot of people can't tolerate retinol. So even though they've sort of become the gold standard in terms of like, I hate to use the word anti-aging, but like anti-aging skincare, a lot of people can't use them, right? Like they are really irritating. They're really drying. They're really flaky. You have to be super, super careful in the sun.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And we've done lots of studies on the safety of urolithin A and it is, you don't get irritation. You don't get sensitivity to it. And There also seems to be this almost like photo protective effect, which I think is very unique. So while I'm still a firm believer that you have to use sunblock, you are getting some protection from the damaging effects of the sun with urolithane.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
They basically, room and board, meaning they get to live inside our gut. They get to digest things we don't eat, like fiber, or in the case of urolithinate, polyphenols, which are plant compounds. So we don't digest those. Our gut microbiome does that for us. And they pay us back in these metabolites. And in this case, urolithinate, called a postbiotic nutrient.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And what we did in a study was we exposed the skin basically to UV light and we applied either a placebo cream or we applied a urolithane cream. And it's called erythema. That's this like
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
inflammation that happens after you've been exposed to the sun and all of that quieted and resolved much more quickly with the urolithin A. So that's really, you know, something that pretty much everybody can tolerate. It's, you know, it's very safe. There's not going to be issues with flaky or sensitivity to it.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And you get that dual effect where it's targeting the intrinsic, like the internal factors associating with aging that mitochondrial decline, but it's also helping to target the number one thing that causes skin aging actually is the damaging effects of the sun. So you're getting sort of that like dual effect
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
It's a different to me. I don't know. Like it's a different equation. So one person it's done in a concentration. So one percent urolithin A in these topicals. What I got is what is found to be effective. I don't know how that like correlates into like a milligram dose that you would take.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But yes, you absolutely like I personally look at it as like, you know, working on my inside and working on my outside. Right. You've got to do it both ways. There have been some reports we haven't studied this. Right. So that when you do take the pill, some people have noticed like I feel like my skin looks better.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. I can't say with the same clarity, like if you take the dietary supplement, like you're going to get skin benefits, like it's going to be minimal. But and sort of same thing if you're using the topical, like it's not going to really become in a meaningful way systemic and going to impact your your muscles.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So if you could absolutely use both, if you're really curious about skin health specifically, that's where you're going to go for the topical. If you're looking for sort of like whole body, then you're going to go for the dietary supplement.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Um, you know, and some people, it's interesting because some people will start with the skin because you actually will see the benefit really quickly with the skin. Whereas when you take like, you know, you said you are starting to feel things in, you know, it's been a little over a month. The expectation I would say is like at the barest minimum a month, you know, it could even take four months.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
That's where our studies continue to see results. Yeah. You know, in today's like Amazon Prime world where people want to see something tomorrow, you got to be patient with this. But the skin you're going to see.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
results pretty pretty quickly so if you're sort of on the fence like is this something that's going to work especially since like i can't go to my doctor and get a mitochondria test like you might want to start with the skin see it yourself and then say oh yeah i want to go and invest in taking the supplement or you might just say like i'm ready like the science is there i i think this is something that would benefit what i'm doing for my health and yeah supplement
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So that's what urolithin A is in a nutshell. What it does is something really, really remarkable. When we talk about cellular health and we talk about aging, right, we have these powerhouses of our cell. When we all think about high school biology, and hopefully we won't really stress out anyone who has long forgotten high school biology, we'll keep it simple. We think of the mitochondria, right?
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Correct. Correct. Yeah. So so, you know, because we're getting to those those mitochondria, which are one of the drivers of aging. Right. And we're we're helping to rejuvenate those mitochondria as we are. Hopefully, like, you know, I think instead of going off a cliff, like it's a much more slow decline into the aging process when you use something like your lipid.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But yes, like the you know, if you're taking the pill, yeah, some of that is going to get to your skin cells, but you're just not going to see the same effect anymore. As if you are putting the topical on there. And, you know, as I said, I personally use both. And I think that's really like the sweet spot.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. I mean, I know I am, you know, not far out from my 50th birthday. I've got about, I think, nine months before it. And I feel better than I felt in my early 40s. And, you know, I just had a DEXA scan like I'm putting on muscle even at this age. Right. And these are the things. But I'm working hard at it. And.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And when I say hard, I don't mean like I deserve a gold star like and I'm doing like an above and beyond. I strength train three times a week and, you know, not anything like that's outrageous. I strength train three times a week.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I, you know, I get plenty of cardio and I make sure that I eat a healthy diet and I prioritize my sleep like I. And then I, you know, of course, do take some targeted supplements. But even there, there's people out there I think are taking like. 50 supplements a day.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I mean, I probably take five, one of which is is Mito Pure, but they're really just, you know, things like a multivitamin and magnesium and some vitamin D and Mito Pure. And so I think anybody can do it.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And automatically we think powerhouse of the cell. It's like a reflex reaction. And that's because these are our cellular batteries. They basically give ourselves the energy they need to do their job. And it doesn't matter whether it's a brain cell or a muscle cell or a skin cell. They all are relying on this energy.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, yeah. So Timeline actually started as a research company, which is just, you know, incredible to me. So it was founded actually in Switzerland, which is in the EPFL, which is basically like the Swiss Institute of Technology by a team of like top scientists and doctors who, and this is really like speaking to my heart, was, you know, the whole idea was
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Applying like a biotech approach to these sort of natural compounds that we find in food and just in nature in general. And to me, what that means is like almost like a pharmaceutical type approach where they are really isolating these compounds, studying their mechanism of action, really learning the safety and efficacy around them, the dosing, how they work.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And it's pretty unique to the supplement world. And so urolithin A has been researched for like 15 years. So there is tons of data and safety on it or data on safety and efficacy on it. But I think we sort of alluded to this earlier, like because there wasn't MitoPure, like no one was really talking about it.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so now all of that research is really being highlighted for consumers to be able to look at and understand. So. The research, I mean, is about to explode, to be honest, I think, in a really exciting way. So there's some more studies that are going to be coming out. I talked a little bit about that one in endurance trained athletes that should be coming out.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
There is some research around immune health. So our immune cells require healthy mitochondria. So there's some really exciting research that should be happening in the upcoming, hopefully in a couple of months.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And then there's some really big institutions that are studying urolithin A. The National Cancer Institute, for example, is looking at it in men with prostate cancer and looking at seeing if it can help resolve some of the inflammatory markers that we see in prostate cancer. The National Institute of Aging is studying it for metabolic health and glucose metabolism.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Buck Institute is studying it for cognitive function. So there is just, you know, like if anybody who's listening goes to like PubMed is basically almost like the Google for scientific research, right? You can like look up anything and you do a search on urolithin A, you will see preclinical. So that means in like animals or cells, preclinical data in so many different aspects of aging, right?
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Even like osteoporosis and reproductive aging. And that data sets the groundwork for human level study. So I think over the next couple of years, we're going to just see a wealth of data coming out that's saying like, oh yeah, this worked in mice. And guess what? It works in humans too. And here's how long, and here's how much, and here's maybe what you need to be on the lookout for.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So the tie in here to urolithin A is this molecule is something that triggers a recycling process of our dysfunctional mitochondria. So as our mitochondria get used, just like anything else with wear and tear, it starts to break down. And that's actually one of the things that contributes to the aging process.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And so it's a really exciting time, I think, to be learning about urolithinib because there's just so much to uncover
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, so MitoPure is the branded version of urolithin A. MitoPure and they're, you know, in transparency, right? If like there are some other brands out there that will have urolithin A, allegedly is the key word there in it.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Just like with any other dietary supplement, there's not always, you know, you talked about this, there's not always truth in what you see on the label and what is being marketed. And so, you know, I think I would just caution anyone, no matter what
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
supplement whether it's creatine or urolithin a or magnesium like you want to choose something that's third-party tested and so mitopure is nsf for sport is clean label certified and asks the fda grass certified all of the research or almost i should say probably all the research that i just talked about that we've published and that's coming is actually using mitopure specifically so
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Even if something else out there is third-party tested, they maybe weren't part of any clinical data to say that their formulation works the same way that Timeline's MitoPure works. So all of the gold standard trials, all of the large institutions are using urolithinamide. I talked about that with the Chinese study.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
We didn't even have anything to do with it, but they wanted MitoPure for their study because of the quality of the dietary supplement. So that's really, yeah. So MitoPure, branded, first clinically tested, validated urolithin A supplement out there.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So as our mitochondria become dysfunctional, our body has this innate ability to recycle them. And urolithin A just helps to upregulate that process. So there's a lot of science mumbo jumbo. I think the key things to sort of take away from that is we don't get urolithin A directly from the diet. We're relying on a healthy gut should we have one, which we'll dive into.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Well, thank you, too, because I think it's like conversations like this where we're all learning and challenging and learning from each other and just building great audiences that trust and respect, you know, their educators and their thought leaders. So thank you for doing that as well. And we love hearing from customers. We love hearing from people. So, you know.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
there's any questions, there's Timeline Longevity on Instagram, our website, Timeline.com. And our customer support team is great. You can find me too. I'm happy to answer any questions at Jen Scheinman Nutrition. And we just, we love to hear from people. And we'll make sure also, Dylan, that all of the studies we talked about are linked in your show notes. They're all open access. They're all
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
available on our website. So anyone who really does want to read the actual original published research that is in, again, third party peer reviewed journals. These are not studies that we just like did nothing with. They're, you know, they've been peer reviewed. So people can do that. They can read for it on their own and make their own decisions.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Awesome. Well, thank you, Dylan. I hope your audience enjoyed it. And yes, more to come.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And what it does is it triggers this recycling process of the cellular energy makers in our cells. So that powerhouse of our cell, we recycle it, we break down, we get rid of the damaged product, the damaged cell components, and we have newer, healthier mitochondria producing more energy for our cells to do their jobs.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah, so absolutely. I think we have within our grasp the ability to change how we age. Now, can we extend lifespan to your point, like Brian Johnson? Like, I don't know, right? And is your lipid A going to make you live from like 100 to 120? Like, I don't know. We don't have the answers to that. That's really hard to study and evaluate.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
But I think you hit on this really, really important critical topic, which is the difference between healthspan and lifespan, right?
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Not just like chronologically how many years you live, but how many of those years are full of vitality and doing the things that we want to do and are free from chronic disease and chronic pain, you know, being in a wheelchair, all of those things that we sort of associate with old age. We can... push those chronic diseases, you know, at bay and slow down their progression.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And I absolutely think that diet exercise, those foundational pieces, you have to do those. There's no free pass. You've got to do those. But I think that things like urolithin A absolutely are taking your health, your wellness, your longevity plan to the next level because they're targeting the biology of how we age. So it's interesting about, you know,
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
I think it was about 10 years ago, this landmark paper came out. It was called The Hallmarks of Aging. And it identified at that point, I believe it was nine biological processes that are happening inside our body, inside our cells that are contributing to how we age. And in order to be a hallmark,
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
scientifically speaking there were things that you could do that could accelerate these processes like smoking obviously is a great example of things that will accelerate aging right and then there are things that you could apply to these processes that would slow down and potentially maybe in cellular models we're seeing reverse I don't think we're in a place right now to claim anything is actually reversing aging and that paper really started these nine hallmarks started the foundation for like other interventions and just studying longevity in medicine
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Dylan, thank you so much. I am so happy to be here. I think we just met sort of recently at A4M. And I think I agree, call you my friend. It's just been such a wonderful experience getting to know you. And I'm so happy to be here talking about mitochondria, cellular health and nutrition and urolithin A with your audience.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And just about a year ago, that paper got a refresh and they added three new hallmarks. So there's 12 hallmarks now specifically that are really the foundation of science looking into longevity and lifespan extension. And interestingly, there's three hallmarks particularly that I think urolithin A plays a role in. So the first one we talked about was mitochondrial dysfunction, right?
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
That is this, and let's just be really like simplistic for a second for your audience. And, and I think, you know, how advanced people are and their understanding of science, like sometimes it's just nice to hear things with a simplistic, um, Understanding. So when we think of the mitochondria, I mean, we're going to talk about energy production.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
They do a ton of other things inside the cells than just energy. But I like to think of the mitochondria as a factory, right, where the raw material is actually the food that we eat and the air that we breathe. And it goes through this complex assembly line. And on the other end is what's called ATP. That's that cellular energy.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And in order to have good cellular energy, a couple of things are going to come into play, right? Like the number of these factories, right? How well these factories function, obviously the quality of the raw materials, the workers and the other ingredients that are on this factory, right? But at the end of the day, that factory will start to break down just like any other factory.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And that is kind of what mitochondrial decline is, is that that factory starts to break down. So that's one of the hallmarks of aging. We also have this ability, as we talked about, to recycle those factories where you will demolish them because you only have so much cellular real estate. Right.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So just like any other factory, like you can keep building new factories, but there's only so much real estate.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
You want to demolish the broken down factories, the broken down mitochondria, take what still works, recycle them and build new ones. And that process is called mitophagy. Another one of the newly added hallmarks of aging was a decline in that mitophagy pathway. And your audience, if you talk about fasting at all and calorie restriction, your audience is probably familiar with the word autophagy.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
That's that cellular recycling. So this is just a very, very targeted form of cellular recycling that happens on the mitochondria. So you're starting to see this increase. influx of dysfunctional mitochondria, right? Higher mitochondria, lower ability to recycle them.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
So you're really getting this mismatch and this imbalance of dysfunctional mitochondria, which has been correlated in so many chronic conditions. And then there's one more interesting hallmark that also came out, which is chronic inflammation, inflamaging, right? This inflammation that's happening inside our cells, which then contributes to damage throughout the cell.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And that's another hallmark of aging. And interestingly, when people take the dietary supplement urolithin A, we do see markers of inflammation come down as well. And so there is this understanding of urolithin A in a supplement form can target three different hallmarks of aging, which is pretty incredible.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
And when you start thinking about health span and how to kind of push back against the things that bring our demise ultimately, right? These chronic conditions, I do think urolithin A can be a really big player in that.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Yeah. So in our studies, we did see exactly, as you said, C-reactive proteins, a great marker of inflammation. And we did see that come down in our studies. So I think that is an interesting marker.
The Dylan Gemelli Podcast
Episode #13 Featuring Registered Dietician Jen Scheinman! THE MITOCHONDRIA and UROLITHIN A EPISODE!! The role of mitochondria in cellular health, In depth analysis of Urolithin A , Gut Health's impact on mitochondria, MITOPURE and more!!
Again, whether you're using urolithin A or anything, I think that's an important thing you want to be asking your doctor to check because it is really helping to assess the full body inflammation that's happening. Now, when we're talking really just about mitochondrial health and testing in general, it does get a little more tricky because...