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👤 PersonAppearances Over Time
Podcast Appearances
Hopefully the next version will be even better, and that way you're already a built-in spokesperson for it.
Right, right, right.
Okay, so I'm going to go ahead and move on to our next segment when AI starts designing undruggable medicines.
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All right.
So let's say you're a drug discovery lab.
You know which protein is driving a disease.
And if you don't know, a protein is basically a tiny machine inside cells that does a specific job.
So you've heard of alpha fold, folding proteins, things like that.
And you even have its 3D structure, which is like knowing the exact shape of that machine.
But every time you try to design a drug to stick to it, nothing works.
In pharma, people often call these undruggable targets.
That just means this protein really matters for the disease, but none of our usual drug tricks can hit it in a clean way.
A team at MIT and several partner labs just built an AI model aimed straight at that frustration.
It's called BoltsGen.
Its job is to design new protein binders for hard cards.
A binder is a molecule that latches onto a specific target in the body.
If you can get a binder that sticks tightly and only where you want, you have the starting point for many modern drugs like antibodies or engineered proteins.
So what does the AI do?