Kat Bohannon

It's very hard to enroll human women in phase one clinical trials. So that's that moment where you actually start trying to test out a drug. You're not in rats anymore. You're in a human body. Okay. And you try and see what are the side effects? What's up? Just enrolling enough women is presently a problem.

I think it's both. I think it's bidirectional. I think there's a lack of trust among women who might want to participate.

Yeah.

But the thing about heart disease that's so interesting is that we did have that really male model for a long time, which is that crushing pain on the chest and the tingle down the arm and these like classic, typically male symptoms. And we're finally getting campaigns out to be like, yeah, actually, do you feel like you have indigestion? Right.

And the stomach, which definitely doesn't trigger are slightly more likely to have anxiety disorders at all, which women also get more because it's like, so is it heartburn or am I dying?

So it's complicated, but it is starting to save lives. Yeah. Yeah. That like just take your body seriously.

Women are 40% more likely to be diagnosed with sleep disorders. We still don't entirely know why. I'm going to take a drug like Ambien to try and get some sleep, right? But then we find out when the car crash data comes filtering back in that female patients are getting in car crashes on their damn morning commutes more.

than male patients who'd taken it the night before because the drug is being metabolized differently in our bodies. It's exiting our bodies in different ways. It's effects on the tissues. And we're only just figuring it out because of what, car crash data?

Yeah, so the FDA finally- Wait till that comes in and we'll make a decision. Yeah, we're just gonna, so yeah. So at the moment they were like, okay, this is a while back. They said, okay, Ambien, you should take half the dose if you've got ovaries. But at that point it had been on the market for 21 years. Oh my God.

The weird thing about ears is that primate hearing changed dramatically. Well, ancestral primate hearing. When our mammalian ancestors moved into the trees, most primates still up there, right? Then our hearing had to change. We needed to be able to hear one another through this weird new environment and we couldn't bounce sound off the ground.

It was just this like, and there's leaves and shit in between us. We could be far So we needed to be able to produce and hear lower pitches than most other mammals. But the females needed to retain those higher pitches because our babies make very high pitched sounds. And it's absolutely true that human women still have a little of that legacy of retaining those higher pitches over our lifespan.

Yeah. Now, remember, this doesn't mean just because you are a female person that it is your destiny to have babies. We're talking about evolutionary influences. Let me just go ahead and say that. Right? The reason you can hear the way you do is for many reasons in communicating with people. Okay.

However, it is true that female hearing is especially attuned to a range of pitches that tends to be associated with human babies' cries. True. That is true. Most people who are biologically male around age 25 or so will start cutting off the top range of the pitches that they can hear. It's just a predictable slope.

It's not like you need a hearing aid when you're 30, but it's just that predictable slope of that high end of human hearing, you start losing it. It's just like an aging thing.

They legit cannot hear you. They cannot hear you. It doesn't explain why they don't care. Sure, that's a different. That's just sexism and we've talked about how that's real.