Nick Norwitz

But however, there's an obstacle to clinical implementation of these diets broadly, and that is some people have these astronomical jumps in cholesterol, in particular LDL cholesterol, and that scares physicians. Just reinforcing what you said, but the reason this is so important is it's a deterrent from prescribing these diets to people who could

But however, there's an obstacle to clinical implementation of these diets broadly, and that is some people have these astronomical jumps in cholesterol, in particular LDL cholesterol, and that scares physicians. Just reinforcing what you said, but the reason this is so important is it's a deterrent from prescribing these diets to people who could

But however, there's an obstacle to clinical implementation of these diets broadly, and that is some people have these astronomical jumps in cholesterol, in particular LDL cholesterol, and that scares physicians. Just reinforcing what you said, but the reason this is so important is it's a deterrent from prescribing these diets to people who could

genuinely benefit from them as a metabolic health therapy. So it's a critical question to answer. One, who is susceptible to these increases in LDL? Because it's only a minority of people. So it's a minority, but it is a decent population. Why in some people and not others? We need to identify that population. What's the mechanism?

genuinely benefit from them as a metabolic health therapy. So it's a critical question to answer. One, who is susceptible to these increases in LDL? Because it's only a minority of people. So it's a minority, but it is a decent population. Why in some people and not others? We need to identify that population. What's the mechanism?

genuinely benefit from them as a metabolic health therapy. So it's a critical question to answer. One, who is susceptible to these increases in LDL? Because it's only a minority of people. So it's a minority, but it is a decent population. Why in some people and not others? We need to identify that population. What's the mechanism?

And then also what's the risk associated with the high LDL in different contexts? And we need this information in order to promote the adoption of ketogenic diets for a broad range of conditions and properly treat people on an individual basis. So with that framing,

And then also what's the risk associated with the high LDL in different contexts? And we need this information in order to promote the adoption of ketogenic diets for a broad range of conditions and properly treat people on an individual basis. So with that framing,

And then also what's the risk associated with the high LDL in different contexts? And we need this information in order to promote the adoption of ketogenic diets for a broad range of conditions and properly treat people on an individual basis. So with that framing,

I would say one really interesting observation that explains why only a minority of people see increases in LDL on low-carb ketogenic diets is that there is an inverse association between your BMI and LDL change, meaning the leaner you are, the higher your LDL goes.

I would say one really interesting observation that explains why only a minority of people see increases in LDL on low-carb ketogenic diets is that there is an inverse association between your BMI and LDL change, meaning the leaner you are, the higher your LDL goes.

I would say one really interesting observation that explains why only a minority of people see increases in LDL on low-carb ketogenic diets is that there is an inverse association between your BMI and LDL change, meaning the leaner you are, the higher your LDL goes.

Mine's like 500, 550. And we can get into the saturated fat or something later.

Mine's like 500, 550. And we can get into the saturated fat or something later.

Mine's like 500, 550. And we can get into the saturated fat or something later.

We can talk about my profile later, the contributions to that. But with respect to the literature, we did a meta-analysis of the 41 human randomized controlled trials with low-carb diets where we had the information to look at LDL changes and lipid changes. And what we found was if you broke it up by BMI category, The only group of studies where LDL went up was BMI under 25, the lean group.

We can talk about my profile later, the contributions to that. But with respect to the literature, we did a meta-analysis of the 41 human randomized controlled trials with low-carb diets where we had the information to look at LDL changes and lipid changes. And what we found was if you broke it up by BMI category, The only group of studies where LDL went up was BMI under 25, the lean group.

We can talk about my profile later, the contributions to that. But with respect to the literature, we did a meta-analysis of the 41 human randomized controlled trials with low-carb diets where we had the information to look at LDL changes and lipid changes. And what we found was if you broke it up by BMI category, The only group of studies where LDL went up was BMI under 25, the lean group.

Overweight, class one obesity, no increase. Class two obesity, LDL actually went down. And if you look at the individual participant level data, there was an inverse association across the BMI spectrum, where the leaner you were, the higher your LDL went. So this is encoded in the human randomized controlled trial literature. And I'll give a big hat tip to my friend Adrian Sotomoto, who is the...

Overweight, class one obesity, no increase. Class two obesity, LDL actually went down. And if you look at the individual participant level data, there was an inverse association across the BMI spectrum, where the leaner you were, the higher your LDL went. So this is encoded in the human randomized controlled trial literature. And I'll give a big hat tip to my friend Adrian Sotomoto, who is the...