Episode 5: Enhancing Patient Safety | Gianluca Trifirò

In our latest episode, we dive into an important study by Dr. Massimo and Dr. Gianluca which examins the agreement between different drug interaction checkers (ICs) when evaluating interactions involving widely used proton pump inhibitors (PPIs). PPIs are frequently prescribed for treating acid-related conditions and preventing medication-induced ulcers, especially in older patients with multimorbidity and polypharmacy. These interactions are often complex, involving increased gastric pH (reduction of absorption) and metabolism through CYP3A4 and CYP2C19 enzymes. However, this study reveals significant inconsistencies between the summary of product characteristics (SPCs) and five individual widely-used ICs.   The podcast covers:  - How different ICs (like INTERCheck WEB, Micromedex, Lexicomp, Epocrates, and drugs.com) identify and classify potential interactions with PPIs (including omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole).- The alarming discrepancies between the IC data and official product summaries (SPCs), and how this impacts clinical decision-making. - Why healthcare professionals should use multiple sources and collaborate closely in managing complex medication regimens, especially in elderly patients. Listen to learn more about the findings of this study and how to improve patient safety and ensure the accurate identification of drug interactions that can affect patient outcomes.

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