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Discovery Engines – with Nabil

Accelerating Cancer Research - Hani Goodarzi of Arc Institute, UCSF, Exai Bio

20 Feb 2025

Description

Hani Goodarzi is Quantitative and Computational Biologist, Core Investigator at the Arc Institute, Associate Professor at UCSF, and co-founder of Exai Bio and Vevo Therapeutics. Episode links and chapters below.Hosted by Nabil Laoudji. Support the podcast! Subscribe to our newsletter. Thanks for watching 🙏🤙Episode Links:Arc InstituteGoodarzi LabExai BioVevo TherapeuticsUCSF Cancer CenterHani's LinkedInGreg Brockman's PostNCI Cancer StatsChapters: (00:00) - Teaser (02:12) - Episode Introduction & Preview (07:35) - Hani’s Path Into Quantitative and Computational Biology (11:55) - The Emerging Promise of Foundation Models Such as Evo 2 (15:53) - Dry Side vs. Wet Side of Biology (22:23) - Pivoting Into AI for Life Science From Unrelated Domains, and the Importance of Culture in Cross-Functional Teams (27:28) - How to Develop Multidisciplinary Teams: Brutal Honesty (30:07) - How Arc Institute’s Org and Funding Structure Enables Innovative Science (36:24) - How Tech Founders Are Pushing Biotech Innovation (39:07) - Hani’s Collaboration with NVIDIA and Greg Brockman of OpenAI (43:57) - The Science Behind Exai’s Early Cancer Detection Platform (52:05) - DNA Methylation to Improve Cancer-Specific Signals From Blood (55:25) - UCSF’s Application of This Technology for Breast Cancer Detection (58:34) - How Startups Help Bridge the Science “Valley of Death” (01:04:24) - Supporting Hani’s Work Through Scientific Contributions, Evangelism, and Applying the Scientific Method Across DisciplinesConnect With Us: Twitter Bluesky LinkedIn Instagram Newsletter Feedback or questionsPlatforms: YouTube Apple Podcasts Spotify Podcasts

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