Bipolar in Pregnancy

Just the other day I received a text from one of our wonderful FM attendings in our group concerned about refilling a patient’s Lamictal in early pregnancy. When asked if that was acceptable to do, I quickly answered ABSOLUTELY. We’ve come a long way in understanding bipolar disorder and a long way since lithium was first described for its use. While its use in psychiatry dates to the mid-19th century, the widespread discovery of lithium is usually credited to Australian psychiatrist John Cade who introduced it for mania in 1949. The first randomized trial was published in 1954 showing efficacy for this mental health condition. The drug was not US FDA approved for treatment of bipolar disorder until 21 years later in 1970. Thankfully, now- safer options of medical therapy are available for reproductive age women. In this episode we will summarize the data on medical therapy for bipolar disorder. Which medications are preferred? Are serum drug levels recommended? Does lithium really cause Epstein's Anomaly? And what drastic move did the UK perform to reduce fetal exposure to some medications commonly used for bipolar disorder in reproductive age women? We’ll explain it all in this episode.

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