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Dr. Joseph Mercola - Take Control of Your Health

How Gut Inflammation Sparks Insulin Resistance - AI Podcast

16 Jul 2025

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Story at-a-glance Inflammation in your colon triggers insulin resistance by sending nerve signals from your liver to your pancreas, even before your blood sugar rises A study showed that leaky gut activates a liver stress response, which tells your pancreas to expand insulin-producing cells in preparation for metabolic stress This entire response happened without weight gain or excess sugar intake, proving gut inflammation alone drives insulin imbalance You can track this hidden process using a test called HOMA-IR, which reveals how hard your body is working to control blood sugar — often before glucose levels become abnormal Healing your gut with the right kinds of fiber and eliminating inflammatory foods helps restore beneficial butyrate levels, repair your gut lining and lower your risk for insulin resistance

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