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Dr. Joseph Mercola - Take Control of Your Health

How Magnesium and Vitamin D Are Reshaping Mental Health Care

18 Sep 2025

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Mental health issues like depression and anxiety are widespread across the globe. In the U.S. alone, nearly one in five adults is affected by mental illness each year Magnesium plays a central role in brain function, mood regulation, and stress response; deficiency is common and linked to anxiety, depression, poor sleep, and cognitive decline Vitamin D directly influences brain chemistry and inflammation, supports dopamine production, and is frequently low in individuals with mood disorders These two nutrients work synergistically. Magnesium activates vitamin D, while vitamin D enhances magnesium absorption; co-supplementation provides greater mental health benefits than either alone The best way to increase vitamin D is through regular midday sun exposure, while magnesium is increased through supplementation with well-absorbed forms like glycinate, malate, or L-threonate

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