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Dr. Joseph Mercola - Take Control of Your Health

Stress Alters Metabolic Hormone with Health Consequences, Study Shows

13 Dec 2025

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Research from Columbia University shows that psychological stress changes a key metabolic hormone, linking emotional strain directly to energy production and overall health People with healthy mitochondria experience a drop in this hormone under stress, while those with mitochondrial dysfunction show an increase โ€” demonstrating how cellular energy capacity shapes stress resilience Chronic stress overstimulates classic stress hormones like cortisol and adrenaline, disrupting blood sugar control, promoting fat storage, and exhausting your mitochondria โ€” the engines that power every cell Social isolation and loneliness were linked to higher levels of stress-related hormones, suggesting that emotional well-being and physical metabolism are deeply connected Restoring mitochondrial balance through nutrition, regular movement, deep sleep, and meaningful connection helps calm stress chemistry, boost energy, and slow biological aging

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