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Dr. Joseph Mercola - Take Control of Your Health

Taking Melatonin Does Not Increase Your Risk of Heart Failure

20 Dec 2025

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A preliminary American Heart Association (AHA) study linked long-term melatonin use to increased heart failure risk, but a closer analysis shows serious flaws, including lack of peer review and failure to account for confounding variables The study found melatonin users had 90% higher heart failure rates, but data mixed together prescription-only countries with over-the-counter markets, misclassifying many actual users as non-users Moreover, the study failed to account for insomnia severity, psychiatric conditions, other medications, and dosing details, making it impossible to determine if melatonin caused the observed outcomes Decades of peer-reviewed research demonstrates melatonin's cardioprotective effects, including reducing blood pressure, protecting heart tissue, and mitigating oxidative damage, contradicting the study's alarming headlines While supplementation is unlikely to pose serious risks, there are natural ways to optimize your melatonin production, such as getting morning sunlight exposure, keeping a consistent sleep schedule, limiting evening blue light, eating earlier, and practicing stress-reduction techniques

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