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Dr. Joseph Mercola - Take Control of Your Health

The Surprising Role of Cortisol in Alzheimer's

26 Nov 2025

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New research shows that people with Alzheimer's have higher cortisol levels and a skewed cortisol-to-DHEA-S ratio, revealing that chronic stress drives early brain degeneration long before memory loss appears Cortisol, your body's main stress hormone, damages neurons and disrupts energy metabolism when it stays elevated, while DHEA-S acts as a protective neurosteroid that helps your brain resist inflammation and oxidative stress Bioenergetic researcher Georgi Dinkov connected these findings to thyroid and metabolic health, showing that when your cells don't produce enough energy, cortisol rises and accelerates cognitive decline Tracking your cortisol-to-DHEA-S ratio offers a powerful early warning sign for chronic stress and neurodegeneration, allowing you to take preventive action years before symptoms develop You can rebalance these hormones naturally by fueling your metabolism with adequate healthy carbohydrates, improving sleep and light exposure, reducing overtraining, practicing calming breathwork, and using natural progesterone to help quiet cortisol

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