E659 | Max Kufner, Again & Jan Miczaika, HV Capital: Turning CO₂ into Chemicals and Building Europe’s Deep-Tech Playbook

Welcome back to another episode of the EUVC Podcast, your trusted inside track on the people, deals, and dynamics shaping European venture.This week, Andreas Munk Holm is joined by Max Kufner, Co-Founder and CEO of again, and Jan Miczaika, Partner at HV Capital.again is one of those rare European deep-tech stories that blends academic brilliance, industrial execution, and venture pace. Born out of DTU, with roots at Stanford and MIT, again uses gas-eating microbes to turn CO₂ emissions into valuable chemicals and materials. In plain English: they take carbon that’s already in the air (not the ground) and repurpose it into things we use every day, from plastics to fertilizers.Backed by HV Capital, GV, and a handful of top European and US investors, again is on a mission to decouple industrial growth from fossil carbon. But the conversation goes far beyond climate tech.Max and Jan unpack what it takes to build deep tech at venture speed, the reality of talent scarcity in Europe, the cultural differences between US and EU deep-tech ecosystems, and how to navigate board dynamics, milestone-based investing, and the journey to a Series B in a capital-intensive world.Whether you’re a founder, investor, or LP curious about deep tech’s reindustrialisation wave — this one’s for you.Here what’s covered:01:24 | again in one line — gas-eating microbes → chemicals (no oil out of the ground)02:53 | Why HV Capital backed again — climate upside and a chance to redefine European chemicals04:31 | Investor → founder pendulum — why Max went from Atlantic Labs partner back to operator06:20 | The serial founder advantage (and its hidden trap)10:17 | Building deep tech in Europe — talent constraints, optimism gaps, and moving early to the US15:30 | Multipolarity — global operations, risk appetite, and where to spend your time23:38 | Boardcraft — how to use your board (and avoid being over-managed)28:39 | On-air sparring — asset-heavy vs. platform-heavy business models33:17 | Prepping for Series B — risk, IRR, and the difference between validation and scale36:59 | Milestone-based investing in deep tech — bridges, binaries, and how to keep momentum43:12 | LPs and VCs — why deep tech is high-risk and high-alpha46:08 | Founder lessons — customer co-creation, speed, and building fast with scientists48:06 | Final reflections — Europe’s industrial renewal through deep tech

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