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Short Wave

What It's Like Taking Alzheimer's Drugs

03 Mar 2025

Description

There are now two fully approved drugs on the market that can, sometimes, slow down the progression of Alzheimer's disease. Both have been shown to slow down the mental decline of Alzheimer's by more than 25%. But that's in a group of patients—an individual may do much better, or not be helped at all. NPR Science Correspondent Jon Hamilton has been talking to people who've taken these drugs. Today he has the story of two patients to receive them.Interested in more human health stories? Contact us at [email protected]. Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

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Full Episode

0.149 - 23.279 NPR Announcer

These days there's a lot of news. It can be hard to keep up with what it means for you, your family, and your community. Consider This from NPR is a podcast that helps you make sense of the news. Six days a week we bring you a deep dive on a story and provide the context, backstory, and analysis you need to understand our rapidly changing world. Listen to the Consider This podcast from NPR.

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24.099 - 37.221 Regina Barber

You're listening to Shortwave from NPR. Hey, short wavers. Regina Barber here. And today on the show, we're bringing you some Alzheimer's reporting from NPR's brain guy, John Hamilton. Hey, John.

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37.741 - 38.481 Jon Hamilton

Hello, Gina.

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38.501 - 42.003 Regina Barber

Okay. So, John, I hear you got a couple stories for us.

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42.484 - 54.13 Jon Hamilton

That's right. As you may know, there are now two drugs approved by the U.S. Food and Drug Administration to treat Alzheimer's disease. I now know. So I've been checking in with one person who is on each of these drugs to see how they're doing.

54.491 - 56.512 Regina Barber

Okay. So give us some background on these drugs.

57.179 - 76.692 Jon Hamilton

Sure. They are meant for people in the very early stages of Alzheimer's. So, you know, before a person's memory and thinking have gotten really bad. Both of these drugs are given by intravenous infusion and both of them clear out this protein called beta amyloid, which is what forms those kind of sticky plaques that build up in the brains of people with Alzheimer's.

76.752 - 76.973 Regina Barber

Right.

77.353 - 80.195 Jon Hamilton

Oh, and both of these drugs cost more than $25,000 a year. Wow. OK.

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