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The Journal.

The New Hit Depression Treatment? A Ketamine-Derived Nasal Spray

21 Mar 2025

Description

After it was approved in 2019, Spravato, a depression treatment derived from the club drug ketamine, was looking like a dud. But recently it has taken off, and it surpassed $1 billion in annual sales last year for its maker, Johnson and Johnson. Further Listening: -A Lawyer Says He Doesn't Need Help for Psychosis. His Family Disagrees.  -America's Maternal Mental Health Crisis  Further Reading: -J&J’s Ketamine-Derived Drug Is Taking Off  -Big Pharma Walked Away From Mental Health. Why Some Are Coming Back.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Audio
Transcription

Full Episode

0.609 - 17.701 Jessica Mendoza

A quick heads up before we get started. This episode mentions suicide and discusses depression. Please listen with care. So just to start us off, could you introduce yourself, your name, your age, what you do?

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18.735 - 22.756 Sean Fury

My name is Sean Fury. I'm a writer in Fort Worth, Texas. I'm 36 years old.

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23.456 - 31.018 Jessica Mendoza

And I'm seeing some, like a very interesting background there for you. You've got a poster. You've got, is that Creature from the Black Lagoon?

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31.158 - 32.438 Sean Fury

It is. That's my favorite.

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33.679 - 38.22 Jessica Mendoza

Sean loves movies, but he doesn't just love to watch them. He makes them too.

39.14 - 45.561 Sean Fury

Horror is my go-to. We just finished the first leg of a shoot of a horror thriller. It's a vampire film.

46.362 - 47.402 Jessica Mendoza

Why did you want to make this film?

48.415 - 69.18 Sean Fury

You know, to kind of work through my own issues with that depression, anxiety, PTSD. And I chose a vampire type story because I feel like there are times where I felt really low, where I just feel like I'm sucking the life out of my family, my wife. Yeah. So I decided to make that literal and explore it through a vampire film.

72.478 - 78.843 Jessica Mendoza

Sean says depression has been part of his life for as long as he can remember. At times, he says, it's been debilitating.

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