Description
这篇综述文章探讨了阿尔茨海默病（AD）的复杂发病机制，重点关注神经炎症和小胶质细胞的作用。文章指出，淀粉样蛋白-β (Aβ) 斑块和异常tau蛋白缠结是AD的经典病理标志，但炎症反应也被认为是关键因素。此外，文章还讨论了评估神经炎症的体内方法，特别是通过正电子发射断层扫描（PET）成像，并强调小胶质细胞在AD病程中可能具有保护和有害的双重作用。最后，文章提出了针对小胶质细胞活化的潜在治疗策略，以期干预疾病进展。References: Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?[J]. Nature Reviews Neurology, 2021, 17(3): 157-172.
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