这篇研究调查了非抗生素药物对肠道微生物组的影响及其与胃肠道感染风险的关联。研究人员分析了超过一百万人的医疗记录，发现某些药物（特别是洋地黄）会增加感染风险。通过小鼠模型实验，他们进一步揭示了洋地黄通过影响肠道微生物组中的特定细菌（如分段丝状细菌SFB）和调节宿主免疫反应（特别是β-防御素BD-39的表达）来提高感染易感性的机制。最终，这项工作整合了流行病学和实验方法，以阐明药物、宿主、微生物组和病原体之间复杂的相互作用。References: Kumar A, Sun R, Habib B, et al. Identification of medication–microbiome interactions that affect gut infection[J]. Nature, 2025: 1-10.
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