这篇文章重点介绍了功能性淀粉样蛋白作为细菌防御机制的发现和特性。文章详细阐述了大肠杆菌（Escherichia coli）通过产生卷曲纤维（一种由 CsgA 蛋白组成的耐久淀粉样蛋白）来抵御捕食性细菌噬菌体（Bdellovibrio bacteriovorus）的攻击。研究表明，这些卷曲纤维形成物理屏障，保护细菌免受感染，并且这种防御机制在大肠杆菌中广泛存在，甚至对其他捕食者和噬菌体也有效。此外，文章还探讨了其他细菌中不相关的淀粉样蛋白，如铜绿假单胞菌（Pseudomonas aeruginosa）产生的功能性淀粉样蛋白（Fap）系统，也具有类似的防御功能，表明利用淀粉样蛋白覆盖和保护细胞外膜是细菌普遍存在的防御策略。References: Ledvina H E, Sayegh R, Carale R O, et al. Functional amyloid proteins confer defence against predatory bacteria[J]. Nature, 2025: 1-8.
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