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这篇文章概述了一项综合性研究,该研究利用空间蛋白质组学和转录组学技术,揭示了卵巢交界性肿瘤向侵袭性低级别浆液性癌发展的分子机制。研究人员整合了细胞类型分辨的深度视觉蛋白质组学和空间转录组学数据,以识别和验证疾病进展的关键驱动因素,并提出了针对这种化疗耐药性疾病的潜在联合治疗方案。特别指出,微乳头状交界性肿瘤被认为是向低级别卵巢癌转变的中间阶段。最终,该研究通过体内外实验验证了新的药物靶点和治疗策略,为低级别浆液性卵巢癌的精准治疗提供了新的见解。References: Schweizer L, Kenny H A, Krishnan R, et al. Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression[J]. Cancer Cell, 2025.
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