这篇文章概述了一项研究，该研究通过全基因组筛选确定了线粒体电子传递链 (ETC) 是神经元抵抗过度兴奋（兴奋性毒性）致死的主要决定因素。研究发现，降低 ETC 表达能通过减少氧化应激和钙内流来保护痛觉神经元（伤害感受器）免受兴奋性毒性损伤。研究人员还证明，伤害感受器本身就表现出较低的 ETC 表达水平，这赋予了它们抵抗兴奋性毒性和氧化应激的固有能力，并提出ETC 调节是一种通用的细胞策略，可增强细胞对包括辣椒素、毒素和通道病变在内的多种兴奋性刺激的抵抗力。References: Yuan L, Chandel N S, Julius D. Mitochondrial activity tunes nociceptor resilience to excitotoxicity[J]. Cell, 2025.
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