这篇文章重点介绍了利用单细胞 RNA 测序（scRNA-seq）和 Xenium 空间转录组学技术对发育中的人类肠道中间充质细胞（成纤维细胞）多样性进行精细映射的研究。作者定义了五种主要的间充质细胞群，包括上皮下细胞 (SEC)、固有层成纤维细胞 (LPF)、黏膜下成纤维细胞 (SMF)、平滑肌细胞 (SMC) 和罕见的 CXCL13+ 成纤维细胞，并确定了它们在肠道组织内的精确解剖位置。此外，该研究将这一高分辨率空间图谱作为一个基准，评估了人类肠道类器官（tHIOs）的细胞组成和空间组织，发现类器官在很大程度上重现了胎儿肠道的结构，但也存在成熟度和罕见细胞类型（如 CXCL13+ 细胞）方面的差异。最后，通过分析成人十二指肠样本，文章证实了胎儿期确定的成纤维细胞群及其空间分布在成年后得以保留，但其比例有所变化。References: Johnson K F, Dong X, Tsai Y H, et al. Mapping mesenchymal diversity in the developing human intestine and organoids[J]. bioRxiv, 2025: 2025.07. 22.665939.
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