这篇文章详细介绍了一项关于人类肠道内温和噬菌体的广泛研究，温和噬菌体是整合到细菌基因组中的病毒。研究人员通过使用252个细菌分离株和10种不同的诱导条件，包括人类结肠细胞（Caco2）产物，对134个可诱导的原噬菌体进行了表征。一个关键发现是，只有一小部分（18%）计算预测的原噬菌体在纯培养中被诱导，但在合成微生物群落与人类细胞共培养时，诱导率增加到35%，这表明人类宿主相关因子可能作为诱导触发因素。此外，研究确定了整合和切除基因中的非功能性突变是原噬菌体失活或“驯化”的潜在遗传途径，并发现多溶原性（宿主携带多个可诱导原噬菌体）与更高的诱导机会相关。References: Dahlman, S., Avellaneda-Franco, L., Rutten, E. L., Gulliver, E. L., Solari, S., Chonwerawong, M., ... & Barr, J. J. (2025). Isolation, engineering and ecology of temperate phages from the human gut. Nature, 1-8.
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