这份研究介绍了一种名为 wellDR-seq 的高分辨率、高通量单细胞测序方法，该方法能够同时分析单个细胞的全基因组和转录组。研究人员将这项技术应用于雌激素受体阳性（ER+）乳腺癌样本，以探究拷贝数变异（CNAs）与基因表达之间的复杂关系。通过对12名患者的分析，研究确定了 Luminal 激素反应性细胞 是某些 ER+ 乳腺癌的潜在起源细胞，并揭示了近 56% 的拷贝数变异片段与基因表达存在近似线性相关性，从而区分出剂量敏感和剂量不敏感基因，极大地增进了对乳腺癌进展机制的理解。References: Wang, Kaile, et al. "Coalescing single-cell genomes and transcriptomes to decode breast cancer progression." Cell (2025).
No persons identified in this episode.
This episode hasn't been transcribed yet
Help us prioritize this episode for transcription by upvoting it.
Popular episodes get transcribed faster
Other recent transcribed episodes
Transcribed and ready to explore now
Trump $82 Million Bond Spree, Brazil Tariffs 'Too High,' More
16 Nov 2025
Bloomberg News Now
Ex-Fed Gov Resigned After Rules Violations, Trump Buys $82 Mil of Bonds, More
16 Nov 2025
Bloomberg News Now
THIS TRUMP INTERVIEW WAS INSANE!
16 Nov 2025
HasanAbi
Epstein Emails and Trump's Alleged Involvement
15 Nov 2025
Conspiracy Theories Exploring The Unseen
New Epstein Emails Directly Implicate Trump - H3 Show #211
15 Nov 2025
H3 Podcast
Trump Humiliates Himself on FOX as They Call Him Out
15 Nov 2025
IHIP News