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Aaron Boster

👤 Person
887 total appearances

Appearances Over Time

Podcast Appearances

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Wow.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And so low levels of vitamin D pre-puberty also change the risk.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We then think that your body sees an infection and we think we've nailed it down to the kissing flu, to mononucleosis, EBV.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Yeah.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And your body contracts EBV and your immune system identifies it as a bad guy.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And your immune system makes an arsenal of T cells and B cells that make antibodies against EBV.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

What's up?

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

So amen.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Yep.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

That's exactly right.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And so you survived mono because your immune system cleared it and you keep an arsenal against mono the rest of your life.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

But in some people, those same cells that identify mono by accident now identify your brain as mono.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And so that's called cross reactivity, like where the antibody binds to something it's not supposed to.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And when that happens, when that gets set up, we don't know how to undo it.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Now, it's really a little bit interesting because we've known that mono could have potentially been requisite to develop MS.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

But they did a really cool study with the Veterans Administration Hospital with 10 million Americans, like a lot of Americans.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And what they found was 95% of that population has been exposed to mono.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

You have, I have.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

But...

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Of the 800 people in the study with MS, all of them but one had been exposed to mono.