Alex Tarnava
๐ค SpeakerAppearances Over Time
Podcast Appearances
Um, and I was just doing this as a do it yourself project for my own health, but I figured why not? What do I have to lose? I can learn as I go, let's do this. Right. So I proceeded forward and, uh, It only took a few weeks to refine. There wasn't much changes to my formulation to get to work in a mortar and pestle. But then the hard work started.
We quickly realized that doing this in mass, making millions of tablets at high speed is dramatically different for safety, for getting the reaction right, everything, than making 20 in a mortar and pestle, mixing by hand and then hand pressing. It took us a year to... over 2,000 iterative adjustments, and 15 failed scale-up attempts at manufacturing to get our first production-ready tablet. Wow.
We quickly realized that doing this in mass, making millions of tablets at high speed is dramatically different for safety, for getting the reaction right, everything, than making 20 in a mortar and pestle, mixing by hand and then hand pressing. It took us a year to... over 2,000 iterative adjustments, and 15 failed scale-up attempts at manufacturing to get our first production-ready tablet. Wow.
We quickly realized that doing this in mass, making millions of tablets at high speed is dramatically different for safety, for getting the reaction right, everything, than making 20 in a mortar and pestle, mixing by hand and then hand pressing. It took us a year to... over 2,000 iterative adjustments, and 15 failed scale-up attempts at manufacturing to get our first production-ready tablet. Wow.
Since then, we've stopped counting at version 5,000. Right. But we're probably at 10,000 iterative adjustments in the R&D process to get to where we are.
Since then, we've stopped counting at version 5,000. Right. But we're probably at 10,000 iterative adjustments in the R&D process to get to where we are.
Since then, we've stopped counting at version 5,000. Right. But we're probably at 10,000 iterative adjustments in the R&D process to get to where we are.
the water and get in in this open cup and get these small nano bubbles in the 10 to 30 nanometer in range which is critically important so that in in say half a liter of water or 16.8 ounces we're getting over 12 parts per million that's incredible i mean that's really incredible and i think a lot of people uh you know when i talk about hydrogen gas in the water they're
the water and get in in this open cup and get these small nano bubbles in the 10 to 30 nanometer in range which is critically important so that in in say half a liter of water or 16.8 ounces we're getting over 12 parts per million that's incredible i mean that's really incredible and i think a lot of people uh you know when i talk about hydrogen gas in the water they're
the water and get in in this open cup and get these small nano bubbles in the 10 to 30 nanometer in range which is critically important so that in in say half a liter of water or 16.8 ounces we're getting over 12 parts per million that's incredible i mean that's really incredible and i think a lot of people uh you know when i talk about hydrogen gas in the water they're
And I know I told you we have a couple of clinical trials head to head against caffeine after acute sleep deprivation. So in the first study, we showed equivalent improvement in the attention network test to caffeine, but they affected different domains of attention. Caffeine affects alerting, and the hydrogen affected orienting.
And I know I told you we have a couple of clinical trials head to head against caffeine after acute sleep deprivation. So in the first study, we showed equivalent improvement in the attention network test to caffeine, but they affected different domains of attention. Caffeine affects alerting, and the hydrogen affected orienting.
And I know I told you we have a couple of clinical trials head to head against caffeine after acute sleep deprivation. So in the first study, we showed equivalent improvement in the attention network test to caffeine, but they affected different domains of attention. Caffeine affects alerting, and the hydrogen affected orienting.
So we did a bigger, better controlled study with four groups, and it was a crossover design also. So everyone did all therapies. So it was a quadruple crossover, so a crazy design. So there was placebo-placebo, hydrogen-placebo, caffeine-placebo, and caffeine plus hydrogen. And it found that...
So we did a bigger, better controlled study with four groups, and it was a crossover design also. So everyone did all therapies. So it was a quadruple crossover, so a crazy design. So there was placebo-placebo, hydrogen-placebo, caffeine-placebo, and caffeine plus hydrogen. And it found that...
So we did a bigger, better controlled study with four groups, and it was a crossover design also. So everyone did all therapies. So it was a quadruple crossover, so a crazy design. So there was placebo-placebo, hydrogen-placebo, caffeine-placebo, and caffeine plus hydrogen. And it found that...
The hydrogen groups with or without caffeine had a substantially more robust improvement in brain metabolism. So choline to creatine ratios in the brain than the caffeine alone. So hydrogen was basically it's as your brain metabolism slows due to the acute stress of sleep deprivation. Hydrogen is temporarily restoring it back to proper function.
The hydrogen groups with or without caffeine had a substantially more robust improvement in brain metabolism. So choline to creatine ratios in the brain than the caffeine alone. So hydrogen was basically it's as your brain metabolism slows due to the acute stress of sleep deprivation. Hydrogen is temporarily restoring it back to proper function.
The hydrogen groups with or without caffeine had a substantially more robust improvement in brain metabolism. So choline to creatine ratios in the brain than the caffeine alone. So hydrogen was basically it's as your brain metabolism slows due to the acute stress of sleep deprivation. Hydrogen is temporarily restoring it back to proper function.
Well, that's linked to young blood. So anyone who's seen the research where they take an aged mouse and they take the blood of a young mouse and, you know, swap it out like an oil change and it revitalizes the old mouse, their skeletal tissue anyways, that's linked to TET2.