Alexis Fernandez-Preiksa

And like this thing called emotional blunting, it kind of blunts the extremes of your emotions.

Then the cerebellum, this is why you have that coordination impairment, slowed speech, stumbling.

Again, if you watched Wolf of Wall Street when he was really high on quaaludes,

That is why, because it was affecting his cerebellum and that takes care of like, you know, your gait, your stance, your balance, all the things like that, delayed reaction time as well.

And then brainstem, this is the dangerous one.

So if you suppress the GABA, GABAergic receptors in the brainstem, then you're going to have like huge issues with your breathing, like it reduces your respiratory drive and

If you combine it with alcohol, that's when it can become absolutely lethal because they are both central nervous system depressants.

Then when the like 1970s hit, that's when like in the whole history of it, like 10, 20 years after they hit the market, they became huge and like the nightclub scene.

And they were really, really popular because people were mixing them with alcohol.

So it really amplified these sedative effects significantly.

So you become less responsive to your brain.

Sorry, your brainstem becomes less responsive to this carbon dioxide buildup, which reduces your respiratory drive.

And then it doesn't look like this chaotic overdose.

It doesn't look really, really hectic.

sedative overdoses look really peaceful.

People just seem really relaxed, really zoned out, and they just kind of quote-unquote fall asleep, but then they don't fucking wake up.

They die.

And so that is why it's so dangerous because it leads me to the almost last point of this no-sealing effect that a lot of quote-unquote dangerous drugs have.

And a no-sealing effect is where people

The more of the drug you have, the more of the effect you're going to have.