Alice Hancock
speaker
191 appearances
3 recordings
3 series
first heard Jun 2026
last heard 3 Jul
Alice Hancock’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Jun 2026 with 2.
Appearances
From an Ipswich fish and chip shop to the epicentre of Australian politics.
So our study investigated T cells, which are really important immune cells, especially against viral infections.
When they sense danger, they become programmed, they receive their signals, and that program really tells them when to get started, how
how long to divide for and when to stop that response.
That's a really important part of that immune response.
But we also know they're incredibly important when they're dysregulated in autoimmune disease.
So we're really interested in measuring if there was an intrinsic differences in T cells from people with celiac disease versus healthy donors.
So essentially, we recruited people to our study who were healthy or had celiac disease.
We isolated their T cells.
And in the lab, under really controlled conditions, we stimulated them and then we measured them.
And what we found was that the T cells from individuals with celiac disease did behave differently.
Yeah, so that wasn't...
initially surprising to us because our initial hypothesis is that we would see them, their programming would really set them off and they would overextend and overexpand.
But what we found was that the T cells from the individuals with celiac disease, they proliferated okay, but they didn't survive so well.
So one really important finding of our study is that we were able to consistently detect these differences in people with celiac disease who'd been on a gluten-free diet for a really long time.
as well as newly diagnosed people who had only just stopped a gluten-free diet.
And that tells us that those immune differences that we were measuring in the T cell responses wasn't just due to the inflammations of ingesting and eating gluten and was much more likely due to the genetic programming of these cells.
That is exactly what we need to test next.
Look, we know the genetics of autoimmune disease are incredibly complex, and that is also true for celiac disease.
It's incredibly hard to really untangle all of those genetic effects.
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