Babak Javid
👤 PersonAppearances Over Time
Podcast Appearances
I was reflecting on my results and I was thinking, this just doesn't make any sense to me. The prevailing dogma at the time is that with a small amount of error, you induce what's called error catastrophe, where the errors in the new proteins make faulty proteins. machinery in the cell that then makes more errors and it just feeds on itself. And these bugs were extremely resilient.
And that made me take a step back and I thought, what if actually these errors aren't detrimental after all, at least in a moderate amount? And That was my, I guess, aha moment. I have to be honest, at the beginning, I had no idea why this was. We were coming up with lots of different ideas just to explain it.
And that made me take a step back and I thought, what if actually these errors aren't detrimental after all, at least in a moderate amount? And That was my, I guess, aha moment. I have to be honest, at the beginning, I had no idea why this was. We were coming up with lots of different ideas just to explain it.
And that made me take a step back and I thought, what if actually these errors aren't detrimental after all, at least in a moderate amount? And That was my, I guess, aha moment. I have to be honest, at the beginning, I had no idea why this was. We were coming up with lots of different ideas just to explain it.
But after a lot of experimentation and blind alleys and wrong turns, we figured out that what's happening is that this mistranslation is allowing the bacteria to innovate. And that was a really exciting moment. And I kind of coined the term adaptive mistranslation, that sometimes these errors, in the right context and in the right degree, can actually be good for the bug.
But after a lot of experimentation and blind alleys and wrong turns, we figured out that what's happening is that this mistranslation is allowing the bacteria to innovate. And that was a really exciting moment. And I kind of coined the term adaptive mistranslation, that sometimes these errors, in the right context and in the right degree, can actually be good for the bug.
But after a lot of experimentation and blind alleys and wrong turns, we figured out that what's happening is that this mistranslation is allowing the bacteria to innovate. And that was a really exciting moment. And I kind of coined the term adaptive mistranslation, that sometimes these errors, in the right context and in the right degree, can actually be good for the bug.