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Betül Kaçar

👤 Speaker
1813 total appearances

Appearances Over Time

Podcast Appearances

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

So some biological engineers engineered E. coli to fix nitrogen, I believe, not us.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

We use nature's nitrogen fixing bug and engineer it with the nitrogen fixing metabolism that we resurrected using our computational and phylogenetic tools.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

Depends on how we define complication.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

So I will start with one of the most fascinating machineries that we target, which is the translation machinery.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It is a very unique subsystem of cellular life in comparison to, I would say, metabolism.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

And we used to, you know, when we are thinking about cellular life, we think of cell as the basic unit or the building block.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

But from a key perspective, that's not the case.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

One may argue that everything that happens inside the cell serves the translation and the translation machinery well.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

There is a nice paper that called this that the entire cell is hopelessly addicted to this main informatic computing biological chemical system that is operating at the heart of the cell.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It is the translation.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

converts a linear sequence of mRNA into a later folded protein.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

That's the core processing center for information for life.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It has multiple steps.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It initiates, it elongates, it terminates, and it recycles.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It operates discrete bits of information.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

Itself is like a chemical decoding device.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

And that is incredibly unique for translation that I don't think you will find anywhere else in the cell that does this.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

I would divide it into actually even four more additional steps or disciplines than what would it take to study it by the way you described it.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It's a chemical system.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It's the compounds that make it up are chemicals.