Bob Langer
👤 PersonAppearances Over Time
Podcast Appearances
Mine would go, just because of the work I was doing, to what was called a Pathology B study section, and they would review it, and they said, well, Dr. Langer, you know, he's an engineer. He doesn't know anything about biology or cancer. I failed over and over again. Other things, like I failed to get a job in a chemical engineering department as an assistant professor even. Nobody would hire me.
They said actually the opposite. They said, you know, chemical engineers don't do experimental biomedical engineering work. So, you know, they should work on oil or energy. When I first started working on creating these micro or nanoparticles to try to get large molecules to be delivered, I failed over 200 times. I mean, before I finally got something to work. I could go on and on in my failures.
They said actually the opposite. They said, you know, chemical engineers don't do experimental biomedical engineering work. So, you know, they should work on oil or energy. When I first started working on creating these micro or nanoparticles to try to get large molecules to be delivered, I failed over 200 times. I mean, before I finally got something to work. I could go on and on in my failures.
They said actually the opposite. They said, you know, chemical engineers don't do experimental biomedical engineering work. So, you know, they should work on oil or energy. When I first started working on creating these micro or nanoparticles to try to get large molecules to be delivered, I failed over 200 times. I mean, before I finally got something to work. I could go on and on in my failures.
What kept you going during all this failure? I really believed that if we could do this, it would make a big difference in science, and I hoped a big difference in medicine. Secondly, as I did some of it, you know, I could see some of these results with my own eyes.
What kept you going during all this failure? I really believed that if we could do this, it would make a big difference in science, and I hoped a big difference in medicine. Secondly, as I did some of it, you know, I could see some of these results with my own eyes.
What kept you going during all this failure? I really believed that if we could do this, it would make a big difference in science, and I hoped a big difference in medicine. Secondly, as I did some of it, you know, I could see some of these results with my own eyes.
When we were trying to deliver some of these molecules to stop blood vessel growth, I could see we were doing this double blind, but I could still see that we were stopping the vessels from growing. That's such a visual thing.
When we were trying to deliver some of these molecules to stop blood vessel growth, I could see we were doing this double blind, but I could still see that we were stopping the vessels from growing. That's such a visual thing.
When we were trying to deliver some of these molecules to stop blood vessel growth, I could see we were doing this double blind, but I could still see that we were stopping the vessels from growing. That's such a visual thing.
And I also developed these ways of studying delivery out of the little particles by putting certain enzymes in them and putting dyes in a little gel that would turn color if the enzymes came out. And I could see that happening. Like I said, the first 200 times or first 200 designs or more, it didn't happen.
And I also developed these ways of studying delivery out of the little particles by putting certain enzymes in them and putting dyes in a little gel that would turn color if the enzymes came out. And I could see that happening. Like I said, the first 200 times or first 200 designs or more, it didn't happen.
And I also developed these ways of studying delivery out of the little particles by putting certain enzymes in them and putting dyes in a little gel that would turn color if the enzymes came out. And I could see that happening. Like I said, the first 200 times or first 200 designs or more, it didn't happen.
But finally, I came up with a way where I'd see it come out after an hour, after two hours, after a day, after a second day, up to over 100 days in some cases. So I could see with my own eyes this was working. So that made an enormous difference to me, too.
But finally, I came up with a way where I'd see it come out after an hour, after two hours, after a day, after a second day, up to over 100 days in some cases. So I could see with my own eyes this was working. So that made an enormous difference to me, too.
But finally, I came up with a way where I'd see it come out after an hour, after two hours, after a day, after a second day, up to over 100 days in some cases. So I could see with my own eyes this was working. So that made an enormous difference to me, too.
The experiments I was doing weren't that expensive, especially the delivery ones initially because they were in test tubes. I worked probably 20-hour days. And so the expense wasn't that great. And I've always been good at manufacturing time.
The experiments I was doing weren't that expensive, especially the delivery ones initially because they were in test tubes. I worked probably 20-hour days. And so the expense wasn't that great. And I've always been good at manufacturing time.
The experiments I was doing weren't that expensive, especially the delivery ones initially because they were in test tubes. I worked probably 20-hour days. And so the expense wasn't that great. And I've always been good at manufacturing time.
Well, I think it's a great question, and I ultimately think it's a judgment call, and we can never be sure of our judgment. You like to try to think, are these things scientifically possible? I think that's one thing. Secondly, it's good to get advice from people. That doesn't mean you have to take it, but it's good to get advice.