Brady Holmer

But with all cause mortality, too, it's kind of interesting because, you

You know, I know that one of the people who talks about this most is like Peter Atiyah, but you know, the leading cause of death or one of the leading causes of death among older adults is you fall, you break a hip, you're in bed for several weeks, you never recover from that.

Well, what type two fibers are important for, these are the power fibers.

These are what, if you trip over something and you need to catch yourself or you need to just prevent yourself from falling, the type two fibers are what are gonna be responsible for that.

And if you have more power producing fibers, stronger type two fibers,

you're going to be less likely to fall.

Hence, you're going to be less likely to experience these disuse atrophy or these catabolic crises, as you've referred to it before.

And so I think that when you look at a cohort of adults like this one, over 70,000 people who inevitably are probably experiencing falls at older ages, and that could be one of the reasons contributing to their all-cause mortality rate.

they're doing more vigorous activity, they're less likely to fall, they probably have a lower chance of experiencing all-cause mortality.

And so just trying to tie that into maybe a few of the different outcomes in this study, diabetes and all-cause mortality, I think that's why we see the benefit there is because if you're doing more of this high-intensity activity throughout the day, you're engaging more type 2 fibers, and we've got to protect those.

The ones that go first, power and strength decline with age, and that's a result of the loss of type 2 fibers primarily.

Yeah, I think, and I don't know if we've covered it, but I'm sure that there are studies out there because the UK Biobank is so huge and they've published,

hundreds of studies at this point, but I'm pretty positive.

And I can't cite a study off the top of my head.

But I know there are studies linking some of the same UK biobank physical activity data to slower brain aging.

And what's cool about the UK biobank is they literally have measures of not just Alzheimer's risk, but physical atrophying of these different brain areas.

And so, yeah, again, I don't have a study, but I know that they've published studies from the UK biobank showing that

probably dose responses with moderate and vigorous exercise and physical aging of the brain and then lower risks of dementia, Alzheimer's, you name it.

I mean, it's, you know, it's pretty inevitable that you're going to see that risk reduction there.

Yeah.