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Bret Weinstein

πŸ‘€ Speaker
4450 total appearances
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The Joe Rogan Experience
#2427 - Bret Weinstein

With me so far?

The Joe Rogan Experience
#2427 - Bret Weinstein

Yep.

The Joe Rogan Experience
#2427 - Bret Weinstein

Okay.

The Joe Rogan Experience
#2427 - Bret Weinstein

What I realized more than 25 years ago, many people who've heard you and me talk before will have heard us talk about my work on telomeres.

The Joe Rogan Experience
#2427 - Bret Weinstein

So telomeres, you'll remember, are structures at the end of every chromosome that are not genes.

The Joe Rogan Experience
#2427 - Bret Weinstein

They are repetitive sequences.

The Joe Rogan Experience
#2427 - Bret Weinstein

They're written in DNA, but it's basically just a repeated series of letters again and again and again.

The Joe Rogan Experience
#2427 - Bret Weinstein

The telomere, basically the number of repeats that are there, dictates how many times a cell line can duplicate.

The Joe Rogan Experience
#2427 - Bret Weinstein

It loses repeats each time it duplicates.

The Joe Rogan Experience
#2427 - Bret Weinstein

And when it gets down to a critically low number, it stops reproducing.

The Joe Rogan Experience
#2427 - Bret Weinstein

Now, we've talked before about why that system exists.

The Joe Rogan Experience
#2427 - Bret Weinstein

The short version is in creatures like us, it prevents cancers from happening because if a cell line runs away and just starts reproducing, it runs into this limit, the hayflick limit, and stops reproducing.

The Joe Rogan Experience
#2427 - Bret Weinstein

So it prevents cancer, but it limits the amount of repair that we can do in a lifetime.

The Joe Rogan Experience
#2427 - Bret Weinstein

So it causes us to senesce, to age and grow feeble as we do so.

The Joe Rogan Experience
#2427 - Bret Weinstein

But what it said to me when I was doing that work was,

The Joe Rogan Experience
#2427 - Bret Weinstein

that there is a kind of information that can be stored in genomes in DNA that is not protein-oriented.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's not what we would call allelic.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's not written in three-letter codons.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's actually a number stored the same way you would store a variable in a computer program, right?

The Joe Rogan Experience
#2427 - Bret Weinstein

The telomere, the length of the telomere,