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Bret Weinstein

πŸ‘€ Speaker
4450 total appearances
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The Joe Rogan Experience
#2427 - Bret Weinstein

But what there are are a bunch of sequences that were traditionally dismissed as junk DNA.

The Joe Rogan Experience
#2427 - Bret Weinstein

that have been used as a molecular marker in biology for decades.

The Joe Rogan Experience
#2427 - Bret Weinstein

We use something called microsatellites.

The Joe Rogan Experience
#2427 - Bret Weinstein

So a microsatellite is a repetitive sequence in DNA that does not code for a protein.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's just like a telomere in that way.

The Joe Rogan Experience
#2427 - Bret Weinstein

And they vary in length.

The Joe Rogan Experience
#2427 - Bret Weinstein

They vary in length a lot so that you may have a species in which the genome is very homogeneous.

The Joe Rogan Experience
#2427 - Bret Weinstein

But between populations, there will have been change in the length of these microsatellites, changes that, as far as we know, don't make any difference.

The Joe Rogan Experience
#2427 - Bret Weinstein

But if you're a biologist in the field and you want to know

The Joe Rogan Experience
#2427 - Bret Weinstein

If the trees in this valley are more closely related to the trees in Valley A or Valley B, you can look at a particular microsatellite and you can say these trees have a microsatellite at this location that is more similar in length to Population A than to Population B. Thus, with some confidence, we think it's more close.

The Joe Rogan Experience
#2427 - Bret Weinstein

It evolved from Population A, something like that.

The Joe Rogan Experience
#2427 - Bret Weinstein

So we use them as a tool for assessing things like relatedness.

The Joe Rogan Experience
#2427 - Bret Weinstein

But we don't typically think of them as a storage modality for a kind of information that might be useful.

The Joe Rogan Experience
#2427 - Bret Weinstein

So the hypothesis that I'm putting on the table, and by the way, these things are extremely common in the genome.

The Joe Rogan Experience
#2427 - Bret Weinstein

There are many more variable number tandem repeats

The Joe Rogan Experience
#2427 - Bret Weinstein

in the genome than there are genes, right?

The Joe Rogan Experience
#2427 - Bret Weinstein

And my point is, I don't know whether evolution uses them as a place to store variables that then become important in describing creatures, but evolution is a very clever process.

The Joe Rogan Experience
#2427 - Bret Weinstein

And the ability to store a variable, I feel highly confident that there will be many variables stored in many different ways.

The Joe Rogan Experience
#2427 - Bret Weinstein

that there are ways in which you can store a variable in triplet codon language, but they're clumsy, they're crude.

The Joe Rogan Experience
#2427 - Bret Weinstein

So you can have things like...