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Bret Weinstein

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4982 total appearances
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The Joe Rogan Experience
#2427 - Bret Weinstein

in DNA and those integers dictate phenomena like developmental timing, turning on and off something like the growth of one of those phalanx, the phalanges in the fingers, if you could radically increase the

The Joe Rogan Experience
#2427 - Bret Weinstein

number that dictated the length of one of those bones, then selection would effectively be in a position to play with adjacent forms.

The Joe Rogan Experience
#2427 - Bret Weinstein

So am I confusing you or is this making sense?

The Joe Rogan Experience
#2427 - Bret Weinstein

No, it's making sense.

The Joe Rogan Experience
#2427 - Bret Weinstein

So the question is, all right, the telomere is a special case.

The Joe Rogan Experience
#2427 - Bret Weinstein

The telomere exists at the end of a chromosome and it can only exist at the end of a chromosome because of the way it functions.

The Joe Rogan Experience
#2427 - Bret Weinstein

So a telomere is not actually just a string, it's actually a loop.

The Joe Rogan Experience
#2427 - Bret Weinstein

And the telomere loops back and at the very tip there's a little section where the DNA is not double-stranded, it's single-stranded.

The Joe Rogan Experience
#2427 - Bret Weinstein

And that single strand inserts between two other strands of DNA.

The Joe Rogan Experience
#2427 - Bret Weinstein

So if you loop the DNA at the end of the chromosome back,

The Joe Rogan Experience
#2427 - Bret Weinstein

It's called a D-loop.

The Joe Rogan Experience
#2427 - Bret Weinstein

And then you get this one little single-stranded DNA that inserts between a double-stranded and makes a very tiny triple-stranded like cap so that it holds the loop in place.

The Joe Rogan Experience
#2427 - Bret Weinstein

You can't do that in the middle of a chromosome.

The Joe Rogan Experience
#2427 - Bret Weinstein

So it's not like there are telomeres all over the place.

The Joe Rogan Experience
#2427 - Bret Weinstein

But what there are are a bunch of sequences that were traditionally dismissed as junk DNA.

The Joe Rogan Experience
#2427 - Bret Weinstein

that have been used as a molecular marker in biology for decades.

The Joe Rogan Experience
#2427 - Bret Weinstein

We use something called microsatellites.

The Joe Rogan Experience
#2427 - Bret Weinstein

So a microsatellite is a repetitive sequence in DNA that does not code for a protein.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's just like a telomere in that way.