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Bret Weinstein

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4982 total appearances
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The Joe Rogan Experience
#2427 - Bret Weinstein

They are repetitive sequences.

The Joe Rogan Experience
#2427 - Bret Weinstein

They're written in DNA, but it's basically just a repeated series of letters again and again and again.

The Joe Rogan Experience
#2427 - Bret Weinstein

The telomere, basically the number of repeats that are there, dictates how many times a cell line can duplicate.

The Joe Rogan Experience
#2427 - Bret Weinstein

It loses repeats each time it duplicates.

The Joe Rogan Experience
#2427 - Bret Weinstein

And when it gets down to a critically low number, it stops reproducing.

The Joe Rogan Experience
#2427 - Bret Weinstein

Now, we've talked before about why that system exists.

The Joe Rogan Experience
#2427 - Bret Weinstein

The short version is in creatures like us, it prevents cancers from happening because if a cell line runs away and just starts reproducing, it runs into this limit, the hayflick limit, and stops reproducing.

The Joe Rogan Experience
#2427 - Bret Weinstein

So it prevents cancer, but it limits the amount of repair that we can do in a lifetime.

The Joe Rogan Experience
#2427 - Bret Weinstein

So it causes us to senesce, to age and grow feeble as we do so.

The Joe Rogan Experience
#2427 - Bret Weinstein

But what it said to me when I was doing that work was,

The Joe Rogan Experience
#2427 - Bret Weinstein

that there is a kind of information that can be stored in genomes in DNA that is not protein-oriented.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's not what we would call allelic.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's not written in three-letter codons.

The Joe Rogan Experience
#2427 - Bret Weinstein

It's actually a number stored the same way you would store a variable in a computer program, right?

The Joe Rogan Experience
#2427 - Bret Weinstein

The telomere, the length of the telomere,

The Joe Rogan Experience
#2427 - Bret Weinstein

is a count of how many times a cell line is allowed to divide over a lifetime.

The Joe Rogan Experience
#2427 - Bret Weinstein

And what occurred to me all those years ago was that the ability to store a number in the genome is fantastically powerful.

The Joe Rogan Experience
#2427 - Bret Weinstein

What it means, if you could store a lot of numbers in the genome, is that you could describe creatures by allotting something, either a quantity of material or an amount of time in development, that you could specify things in the language of numbers that you can't specify in the language of amino acids.

The Joe Rogan Experience
#2427 - Bret Weinstein

So the hypothesis that I'm putting on the table is that the evolutionary process has built a system in which variables, in which integers are stored