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Bryan Calcott

๐Ÿ‘ค Speaker
2862 total appearances

Appearances Over Time

Podcast Appearances

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

And they are instantly being thrown in the dark, being told that, oh, they're just quacks, they're fringe scientists.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

And those are the ones actually practicing science.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

And you can follow the money back to pharmaceutical companies.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

And it's the same thing with cholesterol.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

People believe cholesterol is bad.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

And yet when you look at it, cholesterol is not bad.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

It is the oxidative stress that damages the cholesterol molecule.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

And guess what?

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

If you control for the confounding variable oxidative stress and you remove oxidative stress, you actually show the complete opposite, that more cholesterol, more positive health outcomes.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

Wow.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

So high cholesterol is healthy?

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

Absolutely.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

If you remove oxidative stress.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

How do you do that?

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

What, oxidative stress?

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

I mean, oxidative stress comes from a lot of things.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

It's mainly mitochondrial breakdown.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

So what happens is when the oxygen enters into the body, goes into the cell, and it's supposed to go into the mitochondria.

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

um if it goes into the mitochondria it's used for oxidative phosphorylation it's used to produce atp that's where the majority of our energy comes from we do have some um anaerobic atp production which comes from the glue breakdown of glucose um so what happens is when the mitochondria starts to break down it's uh the last i think it's enzyme complex four um there's an enzyme called cytochrome c oxidase and that's actually where the last reductive process happens where oxygen attaches to

Digital Social Hour
Erik Huberman vs. Bryan Calcott: Should the Government Protect You From Yourself? | DSH #1753

um when the mitochondria starts to break down because we're lazy eating bad food doing all those kinds of things it starts to develop more of an affinity for nitric oxide and so if the nitric oxide is inside the mitochondria the oxygen can't get in there and it bounces off and it becomes a reactive oxygen species and that reactive oxygen species is literally the root cause of every disease out there the reactive oxygen species what goes over to the dna does damage to the dna so guess what cancer genes are activated like you name it it all comes from oxidative stress