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Carole Hooven, Ph.D.

๐Ÿ‘ค Speaker
1074 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And that turns out to be important that there are some genes in females where the female needs the double dose of those genes.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And if she doesn't have the double dose, as in Turner syndrome,

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

They can get it from mom or dad.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And that's another rabbit hole.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

We could go down.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

There are imprinted genes depending on the parental origin, meaning certain genes are

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

are preferentially expressed or suppressed in the mom's ex versus the dad's for interesting evolutionary reasons, because the mom and dad have competing interests in what happens to the kid.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

That's correct, as far as I understand.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I think that there's some evidence that there's technology now where they could reproduce the

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I think in some rare cases that can happen, but generally the ovaries don't.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

It's short.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

She's going to be shorter.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

But generally they're typical in other ways.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I don't know if that's the total complete difference.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I don't know enough about Turner's, but they turn out to, yes, be important.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And I don't even know if it's well understood.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I think there is actually some research on exactly which genes are typically escaping.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I don't know.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So I just wanted to make the point that... So at this point, we have a high level of testosterone in the fetus that is approaching concentrations in male puberty.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So this is...