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Carole Hooven, Ph.D.

๐Ÿ‘ค Speaker
1074 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Or obesity, do you have to?

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Yeah, I'm glad you brought up the androgen receptors because I think people don't appreciate the fact that one person's 400 is not another person's 400.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I know you talk about this a lot about carrier proteins, but also there's the genetic differences in the receptor itself, which is the CAG repeat, which predict the efficiency of its ability to transcribe the androgen-responsive proteins.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And just the overall concentration, where are your androgen receptors and how highly concentrated are there?

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Of course, it's going to be different in different parts of your brain and body.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So all of that really makes much more complex the interpretation of a single measurement.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So that being said, yeah, I don't know.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I don't know.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I'm coming from a place of thinking about how this all works naturally to promote, especially behaviors that are adaptive.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I'm on progesterone, testosterone, and estrogen.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I'm 59, and I had my ovaries out a couple years ago.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And I have to say, I just want to say when that happened, I was 57.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So I was already in menopause pretty much, and everything changed after that.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

It made a huge difference.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

My hair started falling out.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

My sex drive plummeted.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

No.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I just want to throw that out there because I'm supposed to be an expert in hormones.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And I had my ovaries out at 57 and it had a huge impact.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Yeah.