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Chamath Palihapitiya

πŸ‘€ Speaker
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30518 total appearances
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Appearances Over Time

Podcast Appearances

All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

The coverage is coming out of this phase three clinical trial data release that Lily put out last month.

3535.76 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

So everyone's going...

3541.391 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

crazy over the data, which continues to show pretty amazing results.

3542.954 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

So unlike Terzepatide, which is kind of Lilly's main

3549.413 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

product today, which is a dual agonist.

3554.986 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

It's got two peptides in it that bind to different receptors, the GLP-1, the GIP receptor.

3557.37 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

This other one now also binds to glucagon, which is a third receptor.

3562.258 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

And that glucagon receptor binding peptide causes the cells to increase their metabolism, which actually accelerates fat energy consumption

3566.125 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

over what would typically be muscle energy consumption, it's more likely to burn up fat early on, which causes more quick fat loss, but also reduces muscle loss.

3576.282 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

And some of the other data that's now coming out shows non HDL cholesterol down 27% triglycerides down 41% liver fat down 80% to 80% reduction of liver fat, a one C drops

3589.041 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

from 7.9% to 6% in 40 weeks, which is amazing, by the way, if you're diabetic and your A1C drops that much in a couple of months, it's literally a life-saving product.

3604.295 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

The average user in this phase three trial saw their weight decline from 214 pounds.

3615.449 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

They lost 37 pounds.

3621.757 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

That's compared to six pounds on placebo.

3623.038 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

in 40 weeks.

3626.013 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

And modest side effects, 20% people felt more nauseous than the people that were on the placebo.

3628.102 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

There's a lot of other

3634.208 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

Separate studies that are being done now that are showing significant reductions in inflammatory signaling molecules.

3635.632 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

So systemic signaling of like, hey, cells are in distress, triggers this kind of inflammatory process that can have a lot of other damage to your body, can accelerate aging.

3642.361 View full episode β†’
All-In with Chamath, Jason, Sacks & Friedberg
OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

And so one of the other conversations is that reticrutide might actually be kind of a de-aging drug as well.

3654.657 View full episode β†’