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Charles Piller

đŸ‘€ Speaker
1228 total appearances

Appearances Over Time

Podcast Appearances

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

I drop everything and go directly to reinvestigate that issue to satisfy myself that either the questioner is incorrect or if there was a mistake made that we issue a correction. This happens immediately. Not so with scientific journals. Usually they spend weeks, months or even years without doing anything.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

YleensÀ he jÀttÀvÀt kysymyksen takaisin henkilökohtaisesta tutkijasta, joka on kysynyt. Otetaan esimerkki tÀrkeÀstÀ kokemusta Yliopistosta vuonna 2006. Jyrkikirja Nature kirjoittaa tÀmÀn. TÀmÀ on suuri jyrkikirja, yksi maailman suurimpien koulutuksen tÀrkeimmistÀ jyrkikirjoituksista. Voit sanoa, ettÀ se on samaa mieltÀ koulutuksen jyrkikirjasta, jolla työskentelen.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Nature basically sat on this literally for more than almost two years before doing anything about it. And actually more than two years it turned out to be. Now, what they did is they kicked it back to the University of Minnesota. This is the institution with the most to lose and the least to gain from doing a robust, complete and publicly accessible examination of concerns about one of its scientists' research.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Lo and behold, they went years investigating this. Ultimately the study was retracted, but we didn't get the details of what the University of Minnesota's investigation was. We didn't get those details because they behaved in an incredibly secretive way. I might add that ultimately Sylvain Lesnay, who was implicated in being most involved with the apparent image doctoring in this study,

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

joutui yli yliopistoon, vaikka hÀn oli siellÀ nuori, tÀysi opettaja. Erityisen ongelmallinen, mutta tietenkin suuri ongelma, joka vaikuttaa hÀnelle joutumiseen. Kun ajattelee paperista ja rahoituksesta, jotka olivat kaikkiaan ammeloidipolitiikalla,

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Let me put it this way. I want to make it clear that I agree that amyloid proteins and tau proteins have something to do with Alzheimer's disease. I think where I part ways with the progenitors and supporters of the amyloid hypothesis as the dominant way of looking at the disease is that I don't think they have everything to do with Alzheimer's disease. I think that the way in which that idea has been promoted has squeezed out other ways of thinking about Alzheimer's.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Siksi, ettÀ rahoitus on niin pysyvÀ, ettÀ kun niin paljon huomioita menee yhdessÀ suurin piirtein, se voi olla vaikeaa muiden tutkijoiden mukaan saada ratkaisua niiden mielipiteiden mukaan. Luulen, ettÀ se on tÀmÀn asian tragediaa. Voin kuitenkin lisÀtÀ sen lyhyesti. Olisi ollut suuri mÀÀrÀ huolta ja huoltoa Alzheimerin tilanteessa. Oli paljon sellaista, mikÀ liittyy MLA-hyposiisiin.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

TÀmÀ on yleensÀ siksi, ettÀ suurin piirtein ajatuksena ajatuksesta on suuri tavoite, ja se tekee mahdollisuuden, ettÀ vÀÀrÀ tai vÀÀrÀ tieto on paremmin otettava tutkimusyhteisölle.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

with the dominant way of thinking about disease, even if it's wrong, even if it's based on fraud or misconduct, it's much more likely to pass muster and to be seen as being correct information. But I want to say briefly that

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Vastuun ja huolto on vielÀ mielestÀni pieni osa keskustelua. Suomalaiset ovat, kuten useimmat ihmiset kaikessa elÀmÀssÀ, onnistuneita tekemÀÀn oikean asian, kehittÀmÀÀn ihmisen tietoa ja hyödyntÀmÀÀn ihmisyyttÀ hyödyntÀvÀksi.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Ja vaikka uskon, ettÀ Alzheimerin on huonosti huonosti vaikuttanut haasteisiin, sanon, ettÀ useimmat tutkijat eivÀt ole tuossa kategoriassa. TietyllÀ tapaa ne eivÀt ole. Jos katsotaan tieteellisen rakennuksen, niin on ollut paljon haasteita ja huonosti huonosti kÀrsimyksissÀ, kansalaisen tutkimuksessa, diabeetisen tutkimuksessa, kÀytÀnnössÀ kaikesta. Koska hyvin pieni osa ihmisistÀ kaikessa elÀmÀÀnsÀ kÀsitellÀÀn vaihtelevia vaihtoehtoja.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

But the difference is that unlike heart disease and cancer and diabetes and other very important human ailments,

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

Jotkut ovat nÀhneet monimutkaisen edelleen viime viikkojen aikana. Jotkut ovat nÀhneet vaikka taitoja joissain tapauksissa. Emme ole nÀhneet sitÀ Alzheimerin ongelmassa. Ei ole koskaan ollut tapahtumia, jotka pysyvÀt vaihtelevat kognitiiviset systeemit, jotka ovat niin pysyviÀ ja vaikeita.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

really have created the sort of dementia crisis that we have worldwide with Alzheimer's. And in my view, part of the reason why progress has been slow is that the human brain is an incredibly complex organ and is very difficult to decipher what's going on inside there. So that's one reason. Another reason is that when so much seminal research in the field is based on

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

ajatuksia, jotka ovat olemassa doktoreiden nÀkökulmasta, data-vÀlittÀmisestÀ ja kÀytÀnnössÀ rauhasta. TÀmÀ on toivottavasti ollut ongelma Alzheimerin tutkimuksessa, joten se on monia ongelmia.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

KyllÀ. Luulen kirjassa jotain, jota kutsun amyloidimafiaan. Haluan varmistaa, ettÀ se ei ole todellinen jÀrjestelmÀ tai mafia. Ne eivÀt ole rikkoja, paitsi kun joitakin ihmisiÀ, joilla on alzheimerin ongelmia, kuten amyloidipositiivien jÀrjestelmien jÀrjestelmÀt ja muiden tutkimustieteen liittyviÀ, ovat osallistuneet

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

inappropriate actions have engaged in doctored research. But what I mean by the amyloid mafia is people whose careers and personal fortunes and paydays from pharma companies and scientific reputations and their legacies as scientists are all integral to this idea of this one dominant way of thinking in the field.

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

When you have this enormous set of incentives for professionals in the field who are very powerful and who are often the gatekeepers of knowledge, who are prominent scientists, whose work has been cited many thousands of times, whose ideas tend to dictate the trends in drug development and the trends in scientific thinking. When you have them working in lockstep with each other,

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

to try to reinforce what is ultimately their professional legacy and to prove out one way of thinking in the field, then you can have the effect of forestalling the ideas that might run contrary to that or

Passion Struck with John R. Miles
Alzheimer’s Research, Doctored Data, and the Human Cost | Charles Piller – EP 722

might just complement it in ways if they were not starved for funds, if they were not regarded as a secondary or lesser or not worth pursuing. And I think what you had in the field is this dominance that crowded out other ways of thinking. Now, I'm happy to say that