Charles Piller

So shared decision-making is really important. And I'm curious how the shared decision-making component was so poorly predicted by the pharma industry in this case, where they thought it was going to be a blockbuster drug.

So shared decision-making is really important. And I'm curious how the shared decision-making component was so poorly predicted by the pharma industry in this case, where they thought it was going to be a blockbuster drug.

especially in the case where when it comes to Alzheimer's disease, patients typically, what I've experienced, especially when a loved one has dementia, are almost desperate for anything. They're willing to reach for an experimental drug. They're willing to try anything because they're so desperate based on how devastating the condition is.

especially in the case where when it comes to Alzheimer's disease, patients typically, what I've experienced, especially when a loved one has dementia, are almost desperate for anything. They're willing to reach for an experimental drug. They're willing to try anything because they're so desperate based on how devastating the condition is.

especially in the case where when it comes to Alzheimer's disease, patients typically, what I've experienced, especially when a loved one has dementia, are almost desperate for anything. They're willing to reach for an experimental drug. They're willing to try anything because they're so desperate based on how devastating the condition is.

If that's the case, knowing my knowledge of how the disease develops itself, how it impacts families, how is there such a poor prediction by the pharma industry with it not becoming a blockbuster drug? Where was the disconnect?

If that's the case, knowing my knowledge of how the disease develops itself, how it impacts families, how is there such a poor prediction by the pharma industry with it not becoming a blockbuster drug? Where was the disconnect?

If that's the case, knowing my knowledge of how the disease develops itself, how it impacts families, how is there such a poor prediction by the pharma industry with it not becoming a blockbuster drug? Where was the disconnect?

Yeah, I mean, I think, I can't say for sure, but I think part of it is a pure financial equation. So these are publicly traded companies, they have shareholders, and they need to satisfy their shareholders.

Yeah, I mean, I think, I can't say for sure, but I think part of it is a pure financial equation. So these are publicly traded companies, they have shareholders, and they need to satisfy their shareholders.

Yeah, I mean, I think, I can't say for sure, but I think part of it is a pure financial equation. So these are publicly traded companies, they have shareholders, and they need to satisfy their shareholders.

And so when you spend sometimes billions of dollars developing a drug, you need to have great expectations for how that drug's going to do, or you're not going to be able to do the research and to do the testing that's required. And so I think part of it is purely financial motive.

And so when you spend sometimes billions of dollars developing a drug, you need to have great expectations for how that drug's going to do, or you're not going to be able to do the research and to do the testing that's required. And so I think part of it is purely financial motive.

And so when you spend sometimes billions of dollars developing a drug, you need to have great expectations for how that drug's going to do, or you're not going to be able to do the research and to do the testing that's required. And so I think part of it is purely financial motive.

A lot of this, look, the way we do drug development, it's a financial equation, and they're going to have to somehow justify their sunk costs.

A lot of this, look, the way we do drug development, it's a financial equation, and they're going to have to somehow justify their sunk costs.

A lot of this, look, the way we do drug development, it's a financial equation, and they're going to have to somehow justify their sunk costs.

Yeah. Do you have any issues with the current state of drug development as exists today?

Yeah. Do you have any issues with the current state of drug development as exists today?

Yeah. Do you have any issues with the current state of drug development as exists today?